Evidence map›Paper›PMID 40412584›Full record

ArticlePharmacology, biochemistry, and behavior2025

Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.

Elizabeth Alcantara, Michelle R Doyle, Clara A Ortez, Anne Ilustrisimo, Bloom Stromberg, Amanda M Barkley-Levenson, Abraham A Palmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth AlcantaraDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Michelle R DoyleDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Clara A OrtezDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Anne IlustrisimoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Bloom StrombergDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Amanda M Barkley-LevensonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: aap@ucsd.edu.

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
A Novel Pharmacotherapy for Alcoholism: Evaluation of Reward, Aversion, Compulsivity, Withdrawal & ReinstatementR01AA026281 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALMER, ABRAHAM A · 2018 to 2022
$2.0M
Identification and Characterization of Novel Genetic Mechanisms in Alcohol Use Disorder and Excessive DrinkingK99AA027835 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARKLEY-LEVENSON, AMANDA MALINA · 2019 to 2021
$434k
NIAAA NIH HHS K99 AA027835NIAAA NIH HHS R01 AA026281NIAAA NIH HHS T32 AA007456
6 · The paper itself

Abstract

Methylglyoxal (MG) is an endogenously produced non-enzymatic side product of glycolysis that acts as a partial agonist at GABA

Indexed as

CocaineLactoylglutathione LyaseLocomotionOxycodoneAnimalsMaleMiceMice, Inbred C57BLCocaineGlo1 protein, mouseLactoylglutathione LyaseOxycodoneCocaineConditioned place preferenceGlyoxalaseMethylglyoxalOpen fieldOxycodone

Identifiers

PMID40412584
PMCPMC12360504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.