Evidence map›Paper›PMID 40412395›Full record

SynthesisThe Lancet. Global health2025

Post-pulmonary tuberculosis lung function: a systematic review and meta-analysis.

Sharina Ratnakumar, Sally E Hayward, Emma K Denneny, Lucy P Goldsmith, Rebecca Evans, William Checkley, Delia Goletti, Catherine W M Ong, Mateusz Gotowiec, Junkai Zhu and 2 more

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Post-tuberculosis lung disease.Breathe (Sheffield, England) · 2026
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sharina RatnakumarUCL Respiratory, University College London, London, UK; St George's School of Health and Medical Sciences, City St George's University of London, London, UK.
Sally E HaywardSt George's School of Health and Medical Sciences, City St George's University of London, London, UK.
Emma K DennenyUCL Respiratory, University College London, London, UK.
Lucy P GoldsmithSt George's School of Health and Medical Sciences, City St George's University of London, London, UK; Public Health Research Institute, St George's School of Health and Medical Sciences, City St George's University of London, London, UK.
Rebecca EvansUCL Respiratory, University College London, London, UK.
William CheckleyDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, Johns Hopkins University, Baltimore, MD, USA.
Delia GolettiDepartment of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L Spallanzani-IRCCS, Rome, Italy.
Catherine W M OngInfectious Disease Translational Research Programme, National University of Singapore, Singapore; Division of Infectious Diseases, National University Hospital, Singapore; National University of Singapore Institute for Health Innovation & Technology (iHealthtech), Singapore.
Mateusz GotowiecUCL Respiratory, University College London, London, UK; Department of Methodology, Medical University of Warsaw Institute for Infection and Immunity, Warsaw, Poland.
Junkai ZhuUCL Respiratory, University College London, London, UK.
Jon S FriedlandSt George's School of Health and Medical Sciences, City St George's University of London, London, UK.
Joanna C PorterUCL Respiratory, University College London, London, UK. Electronic address: joanna.porter@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough post-tuberculosis lung disease poses a substantial threat to individuals who have recovered from pulmonary tuberculosis, data showing objective functional impairment in such people are scarce. We did a systematic review and meta-analysis to estimate respiratory impairment after pulmonary tuberculosis disease and examine differences in ventilatory defects.

methodsWe systematically searched Embase, MEDLINE, and CINAHL from Jan 1, 2000, to Dec 13, 2024. We included any study design with data on lung function tests in individuals with a previous diagnosis of pulmonary tuberculosis versus healthy controls. Outcomes extracted from eligible studies included forced expiratory volume in 1 s (FEV

findingsOf the 5594 publications found, data from 19 studies were included for meta-analyses, reporting on 75 960 individuals of whom 7447 had past pulmonary tuberculosis. All studies reporting absolute values, using various levels of adjustment or standardisation, showed that previous pulmonary tuberculosis had a negative effect across all spirometric values: FEV

interpretationPeople who recover from pulmonary tuberculosis have significantly decreased lung function compared with controls, with FEV

fundingBreathing Matters.

Indexed as

LungTuberculosis, PulmonaryForced Expiratory VolumeHumansRespiratory Function TestsVital Capacity

Identifiers

PMID40412395
PMCPMC12287636

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.