ArticleDevelopmental cell2025
Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids.
Abstract read
In one paragraph
Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Development of a vascularized multi-organoid-on-a-chip to model the heart-islet axis in diabetic cardiomyopathy.Bioactive materials · 2026Article
- Sodium tungstate promotes vascularization to support beta cell replacement in diabetes.EMBO molecular medicine · 2026Article
- The comparative cell physiology of stem cell-derived and primary human β cells.Nature reviews. Endocrinology · 2026Review
- Understanding development and cellular plasticity in the pancreas in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Applications of Stem Cell-Derived Islets and Emerging Experimental Platforms to Understand Diabetes.Diabetes · 2026Review
- Stem cell-based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection.Animal models and experimental medicine · 2026Review
- Stem cell-based tactics in the remodeling and treatment of intestinal diseases.Stem cell research & therapy · 2026Review
- Pancreatic organoids and organoid-on-a-chip platforms: from disease modeling to precision therapy.Journal of translational medicine · 2026Review
- Regenerative macrophages enhance stem cell-derived β cell function and engraftment.Science advances · 2026Article
- Engineering the oxygen microenvironment for pancreatic islet transplants.NPJ Regenerative medicine · 2026Review
- Review
- Advances in the differentiation of induced pluripotent stem cells into vascular cells for the treatment of diabetic microvascular disease.Cardiovascular diabetology · 2026Review
- Whole-genome CRISPR screening identifies genetic modifiers of stem cell-derived islet transplantation.Stem cells translational medicine · 2026Article
- Reconstructing the Islets: Advances in 3D Pancreatic Organoid Models for Functional β-Cell Replacement.International journal of molecular sciences · 2026Review
- Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026Review
- Vascular endothelial cells as signaling niches for epithelial stem cells in the skin.Frontiers in cell and developmental biology · 2026Review
- Toward system-level integration of organoids for regenerative medicine.Burns & trauma · 2026Review
- TRAP seq in 3D angiogenesis assays reveals a distinct endothelial translatome associated with early and late stages of morphogenesis.Scientific reports · 2025Article
- Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes.Cell reports. Medicine · 2025Article
- Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Yesl JunDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Kim-Vy Nguyen-NgocDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Somesh SaiMax Delbrück Center for Molecular Medicine, Berlin 13125, Germany; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin 14195, Germany.
R Hugh F BenderDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA.
Winnie GongDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Vira KravetsDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Han ZhuDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Christopher J HatchDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA.
Michael SchlichtingDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA; Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany.
Roberto GaetaniShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Medhavi MallickDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Stephanie J HacheyDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA.
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Stem Cell Institute, University of California, San Diego, La Jolla, CA 92037, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Steven C GeorgeDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
Christopher C W HughesDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA.
Maike SanderDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA; Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Charité-Universitätsmedizin, Berlin 10117, Germany. Electronic address: maike.sander@mdc-berlin.de.
Funding
A 3-D biomimetic human islet to model beta cell function in health and diseaseUC4DK104202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L, GEORGE, STEVEN CARL · 2014 to 2016
$4.9MA 3D vascularized islet biomimetic to model type 1 diabetesUH3DK122639 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES, CHRISTOPHER C. W., SANDER, MAIKE · 2021 to 2023
$3.0MA 3D vascularized islet biomimetic to model type 1 diabetesUG3DK122639 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES, CHRISTOPHER C. W., SANDER, MAIKE · 2019 to 2020
$2.1MNIDDK NIH HHS UC4 DK104202NIDDK NIH HHS UG3 DK122639NIDDK NIH HHS UH3 DK122639
Abstract
Blood vessels play a critical role in pancreatic islet function, yet current methods for deriving islet organoids from human pluripotent stem cells (SC-islets) lack vasculature. We engineered three-dimensional (3D) vascularized SC-islet organoids by assembling SC-islet cells, human primary endothelial cells (ECs), and fibroblasts in a non-perfused model and a microfluidic device with perfused vessels. Vasculature improved stimulus-dependent Ca
Indexed as
Islets of LangerhansOrganoidsPluripotent Stem CellsTissue EngineeringAnimalsBone Morphogenetic Protein 2Bone Morphogenetic Protein 4CalciumCell DifferentiationEndothelial CellsHumansInsulin-Secreting CellsMiceNeovascularization, PhysiologicSignal TransductionBone Morphogenetic Protein 2Bone Morphogenetic Protein 4CalciumCa(2+) imagingdiabetesendothelial cellsengraftmenthuman pluripotent stem cellsisletmicrofluidic deviceorganoidvasculatureβ cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.