Evidence map›Paper›PMID 40411804›Full record

Trial reportSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

Non-Invasive Imaging for the Evaluation of a New Oral Supplement in Skin Aging: A Case-Controlled Study.

Simone Michelini, Maria Elisabetta Greco, Giordano Vespasiani, Federica Trovato, Camilla Chello, Noah Musolff, Carmen Cantisani, Giovanni Pellacani

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simone MicheliniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0000-0002-3374-7384
Maria Elisabetta GrecoDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0009-0008-5067-8190
Giordano VespasianiDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.
Federica TrovatoDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.
Camilla ChelloDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0000-0002-3142-1831
Noah MusolffDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0009-0003-6952-0661
Carmen CantisaniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0000-0003-1807-1539
Giovanni PellacaniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.ORCID https://orcid.org/0000-0002-7222-2951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin aging represents a para-physiological process related to metabolic imbalances, inflammation, proliferative responses, and oxidative stress. Ending the cycle of inflammation, and oxidative stress represents a way to slow the effects of aging. STUDY

objectiveThe aim of our study was to evaluate the benefits of supplements with an herbal mixture based on Venerinase and B-group vitamins, Zinc, and Magnesium in preventing/reducing photoaging by means of objective quantitative analysis of visual skin features obtained by VISIA 2D and stroma and vascular characteristics measured by Optical Coherence Tomography (OCT).

methodsA prospective clinical study was conducted in 40 participants. They were randomized 1:1 to receive the supplement (Giovina) or placebo. Assessments were conducted at Baseline (T0), after 2 months (T1), and after 4 months (T2). The primary endpoint was to obtain a significant improvement in facial photo/chrono-aging in the treatment arm, as assessed through the evaluation of the Griffith scale. Secondary endpoints were to assess significant changes in skin aging objective features (VISIA) and Optical Coherence Tomography (OCT) parameters.

resultsThe treated group showed a significant reduction in the mean Griffith scale score from 4.5 at baseline to 3.76 at T2 (4 months) (p = 0.001). A significant decrease in red areas and a borderline significant reduction in the number of wrinkles have been shown by skin aging objective feature calculation on VISIA 2D photographs. OCT analysis showed a borderline significant reduction in collagen density.

conclusionsThe decrease in vascular pattern and collagen density suggests an anti-inflammatory effect with a potential stromal remodeling in the treated group. This seems to be correlated to the reduction in wrinkles and facial redness.

Indexed as

Dietary SupplementsSkin AgingTomography, Optical CoherenceAdministration, OralAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesSkinTreatment Outcomeantioxidantcollagenfood supplementinflammatory agingskin agingwrinkle

Identifiers

PMID40411804
PMCPMC12103190

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.