ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.Biomechanics and modeling in mechanobiology · 2026Article
- Quantitative lung ultrasound spectroscopy: First comparison with gold standard computed tomography scan and standard lung ultrasound for diagnosis of pneumonia versus cardiogenic pulmonary edema.The ultrasound journal · 2026Article
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12 authors.
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Abstract
The acute respiratory distress syndrome (ARDS) is characterized by pathologic and heterogeneous alterations in the mechanical properties of lung tissue. Although several techniques exist that allow for assessment of global lung mechanics in health and disease, few techniques allow for quantitative assessment of regional mechanics, which is important for understanding the impact of therapeutic interventions on local structure-function relationships. X-ray computed tomography (CT) is a widely available imaging modality for assessment of regional lung structure, given its high spatial resolution, as well as its ability to provide detailed information on regional anatomic and pathologic features. Quantitative computed tomography (qCT) has evolved into an important tool for assessment of regional and global mechanical changes associated with deranged structure-function relationships in many lung diseases, especially ARDS. The purpose of this study was to determine how specific structural and functional characteristics of the acutely injured lung may be altered, as assessed with various qCT imaging metrics. Such alterations may serve as a template for characterizing the severity of ARDS in patients. We evaluated and compared pressure-volume relationships, distensibility, aeration, tissue texture, and parenchymal deformation in healthy and injured lungs of anesthetized pigs, using volumetric CT images obtained during static breath holds from 30 to 0 cmH
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