Evidence map›Paper›PMID 40411707›Full record

ArticleJournal of physiology and biochemistry2025

Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway.

Huayu Shang, Ranggui Ma, Shengju Chen, Hao Deng, Mengyu Li, Shiqiao Zheng, He Zhang, Duo Zhang, Tianai Yang, Ying Yang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huayu Shang *School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Ranggui Ma *School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Shengju ChenSchool of Physical Education, Liaoning Normal University, Dalian, China.
Hao DengSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Mengyu LiSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Shiqiao ZhengSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
He ZhangDepartment of Physical Education, Central South University, Changsha, China.
Duo ZhangSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Tianai YangSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Ying YangCollege of Physical Education and Health, North Campus, Wenzhou University, Chashan University Town, Wenzhou, 325035, P. R. China.
Zhi XiaCollege of Physical Education and Health, North Campus, Wenzhou University, Chashan University Town, Wenzhou, 325035, P. R. China. zhixia.ep@wzu.edu.cn.

Funding

Basic Scientific Research Project of Wenzhou Y20220209 and Y20240018Expert Centre Foundation of Sichuan Province A2020SCZJJCA01Jiangxi Provincial Science Fund for Distinguished Young Scholars 20202ACBL216004Natural Science Foundation of China 31900842 and 31960192Natural Science Foundation of Sichuan Province 2023NSFSC1524Scientific Research Fund of Zhejiang Provincial Education Department Y202352718 and Y202454649Zhejiang Provincial Natural Science Foundation of China LY23C110001
6 · The paper itself

Abstract

Eccentric exercise is known to induce more pronounced muscle damage associated with delayed-onset muscle soreness than concentric exercise. This study aimed to investigate whether AMP-activated protein kinase (AMPK) pathway participates in control of mitophagy in rat skeletal muscle in response to downhill running. Eighty-eight male Sprague-Dawley rats were exercised on a treadmill tilted at 16° decline at 16 m·min

Indexed as

AMP-Activated Protein KinasesMitochondria, MuscleMitophagyMuscle, SkeletalPhysical Conditioning, AnimalRunningAminoimidazole CarboxamideAnimalsMaleMicrotubule-Associated ProteinsPeptidyl-Prolyl Isomerase FPhosphorylationRatsRats, Sprague-DawleyRibonucleotidesSignal TransductionAICA ribonucleotideAminoimidazole CarboxamideAMP-Activated Protein KinasesAnxa3 protein, ratMicrotubule-Associated ProteinsmTOR protein, ratPeptidyl-Prolyl Isomerase FRibonucleotidesTOR Serine-Threonine KinasesAMP-activated protein kinaseDownhill treadmill runningFK506-binding protein 8MitophagySkeletal muscle

Identifiers

PMID40411707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.