Evidence map›Paper›PMID 40411684›Full record

ArticleMolecular neurobiology2025

The Impact of Maternal Obesity and Deprivation On Energy Metabolism, Oxidative Stress and Brain Antioxidant Defense in the Neurodevelopment of Offspring in the Short, Medium and Long Term.

Mariella Reinol Steiner, Aline Haas de Mello, Daniele Hendler Salla, Catarina Barbosa Chaves Bressan, Rayane Luiz Mendes, Mariana Pacheco de Oliveira, Larissa Espindola da Silva, Bruna Barros Fernandes, Igor Ramos Lima, Rubya Pereira Zaccaron and 4 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mariella Reinol SteinerLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil. nutrimarireinol@gmail.com.
Aline Haas de MelloDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA.
Daniele Hendler SallaLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Catarina Barbosa Chaves BressanLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Rayane Luiz MendesLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Mariana Pacheco de OliveiraLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Larissa Espindola da SilvaLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Bruna Barros FernandesLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Igor Ramos LimaLaboratory of Experimental Pathophysiology - Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Rubya Pereira ZaccaronLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Gislaine Zilli RéusTranslational Psychiatry Laboratory, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina (UNESC), Criciúma, Brazil.
Paulo Cesar Lock SilveiraLaboratory of Experimental Pathophysiology - Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Emílio Luiz StreckNeurometabolic Diseases Laboratory - Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Gislaine Tezza RezinLaboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current global obesity epidemic is often associated with changes in dietary habits and lifestyle. Increasing evidence from both observational and experimental animal studies has highlighted the relationship between prenatal exposures and an increased predisposition to metabolic and cognitive disorders, as well as obesity in adulthood. In this study, we used a rodent model to investigate brain energy metabolism by assessing mitochondrial respiratory chain complexes I and II, along with oxidative stress markers (DCF) and antioxidant defenses (GSH and SOD), aiming to identify potential alterations in the central nervous system during offspring neurodevelopment. Our results demonstrated increased body weight and mesenteric fat accumulation in early life and adolescence, along with an imbalance in brain energy metabolism when maternal obesity and early-life stress (maternal deprivation) were combined. By exploring the complex interactions between gestational exposures and long-term behavioral and metabolic outcomes in an experimental model, our findings contribute to a better understanding of the developmental origins of health and disease.

Indexed as

AntioxidantsBrainEnergy MetabolismMaternal DeprivationObesityOxidative StressPregnancy in ObesityPrenatal Exposure Delayed EffectsAnimalsBody WeightFemaleMalePregnancyRatsRats, WistarTime FactorsAntioxidantsAntioxidant defenseBrainEnergy metabolismMaternal deprivationMaternal obesityOxidative stress

Identifiers

PMID40411684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.