Evidence map›Paper›PMID 40411649›Full record

ArticleClinical oral investigations2025

Recent innovations in endodontic irrigation and effects on smear layer removal: an ex-vivo study.

Ayfer Atav, Alessio Zanza, Aysenaz Gunes, Luca Testarelli, Massimo Galli, Qorri Erda, Michela Relucenti, Orlando Donfrancesco, Gianluca Gambarini

Abstract read
In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ayfer AtavAtlas University, Faculty of Dentistry, Department of Endodontics, Istanbul, 34408, Turkey. carminaayfer@hotmail.com.ORCID http://orcid.org/0000-0003-0270-8646
Alessio ZanzaSapienza University of Rome, Department of Oral and Maxillo-Facial Sciences, Via Caserta 06, 00161, Rome, Italy. alessio.zanza@uniroma1.it.ORCID http://orcid.org/0000-0002-2062-8140
Aysenaz Gunesİstinye University, Faculty of Medicine, Stem Cell and Tissue Engineering, Istanbul, 34396, Turkey.ORCID http://orcid.org/0000-0003-2935-1827
Luca TestarelliSapienza University of Rome, Department of Oral and Maxillo-Facial Sciences, Via Caserta 06, 00161, Rome, Italy.ORCID http://orcid.org/0000-0003-3904-3000
Massimo GalliSapienza University of Rome, Department of Oral and Maxillo-Facial Sciences, Via Caserta 06, 00161, Rome, Italy.ORCID http://orcid.org/0000-0003-1974-677X
Qorri ErdaDepartment of Dentistry, Faculty of Medical Sciences, Albanian University, Tirana, Albania.ORCID http://orcid.org/0000-0002-5079-6815
Michela RelucentiSapienza University of Rome, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Section of Anatomy, Electron Microscopy Unit, Laboratory "Pietro M. Motta", 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-3805-9505
Orlando DonfrancescoDepartment of Life Science, Health and Health Professions, Link Campus University, 00165, Rome, Italy.ORCID http://orcid.org/0000-0003-4544-8928
Gianluca GambariniSapienza University of Rome, Department of Oral and Maxillo-Facial Sciences, Via Caserta 06, 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-5645-1965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the cleaning efficacy of different irrigation activation techniques in removing smear layers from root canals. MATERIALS AND

methodsNinety lower premolars with straight root canals were assigned to six experimental groups (n = 15 each): control group, conventional irrigation, passive ultrasonic activation (PUI), distilled water laser-activated irrigation (LAI), PulpSucker irrigation, and iVac irrigation. Each canal was shaped to size 30/04 and irrigated with 5% NaOCl. The final rinse was performed according to the experimental group. After chemo-mechanical procedures, the teeth were split longitudinally and subjected to scanning electron microscopic (SEM) analysis for each root canal third (coronal, middle, and apical). The presence of smear layer was evaluated using a 5-grade scoring system at 500× and 1000× magnification. Following the Shapiro-Wilk test, data were statistically analyzed using the nonparametric Kruskal-Wallis test, followed by the post-hoc Dunn test with Bonferroni correction (α = 5%), to compare the effectiveness of smear layer removal. The Friedman test and post-hoc Wilcoxon signed-rank test with Bonferroni correction (α = 5%) were performed to assess significant differences in smear layer removal among the different tooth thirds.

resultsActivated irrigation techniques significantly outperformed conventional irrigation (p <.05), with the iVac technique demonstrating the best results in smear layer removal in the apical third. LAI and PUI showed comparable results across all tooth thirds. Significant differences in cleaning efficacy were observed among the different tooth thirds within each experimental group, with the apical third exhibiting the highest presence of smear layer.

conclusionWithin the limitations of the study, irrigant activation demonstrated higher efficiency in smear layer removal from root canal systems compared to conventional irrigation techniques. iVac showed the best cleaning performance in each third, particularly in the apical third. CLINICAL RELEVANCE: iVac technology offers significant potential for improving clinical outcomes.

Indexed as

Root Canal IrrigantsRoot Canal PreparationSmear LayerTherapeutic IrrigationBicuspidHumansIn Vitro TechniquesMicroscopy, Electron, ScanningSodium HypochloriteRoot Canal IrrigantsSodium HypochloriteEndodonticsIrrigationiVacLaserSEM

Identifiers

PMID40411649
PMCPMC12103479

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.