Evidence map›Paper›PMID 40411608›Full record

ArticleNeuroradiology2025

Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [

Leonie Zerweck, Uwe Klose, Constantin Roder, Deborah Staber, Emely Renger, Ganna Blazhenets, Kathrin Grundmann-Hauser, Philipp T Meyer, Ulrike Ernemann, Till-Karsten Hauser

Abstract read
In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leonie ZerweckDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany. leonie.zerweck@med.uni-tuebingen.de.
Uwe KloseDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany.
Constantin RoderDepartment of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany.
Deborah StaberDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany.
Emely RengerDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany.
Ganna BlazhenetsDepartment of Nuclear Medicine, Medical Center- University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kathrin Grundmann-HauserInstitute for Medical Genetics and Applied Genomics, University Hospital Tuebingen, Tuebingen, Germany.
Philipp T MeyerDepartment of Nuclear Medicine, Medical Center- University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ulrike ErnemannDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany.
Till-Karsten HauserDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreath-hold functional MRI (bh-fMRI) is able to quantify cerebrovascular reactivity. Vessel stenoses can lead to delayed hemodynamic responses. We aimed to investigate whether delay correction improves the quality of bh-fMRI compared to the diagnostic standard [

methodsThe bh-fMRI data sets of 25 patients with Moyamoya Angiopathy were analyzed retrospectively without and with delay correction. Delay correction was calculated using time-to-peak (TTP) maps derived from dynamic susceptibility contrast (DSC) perfusion MRI. [

resultsThe agreement between bh-fMRI and [

conclusionDelay correction improves the quality of bh-fMRI and seems to be helpful in clinical practice.

Indexed as

Breath HoldingCerebrovascular CirculationMagnetic Resonance AngiographyMagnetic Resonance ImagingMoyamoya DiseasePositron-Emission TomographyAdolescentAdultFemaleHumansMaleMiddle AgedOxygen RadioisotopesRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesOxygen RadioisotopesRadiopharmaceuticalsWater[15O]water PETBreath-hold fMRIDCE MRIMoyamoya angiopathy

Identifiers

PMID40411608
PMCPMC12494653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.