Evidence map›Paper›PMID 40411588›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

MeDeMSA care study protocol: developing personalized best medical care with integrated mobile palliative and telemedicine support for individuals with multiple system atrophy.

Alessandra Fanciulli, Bianca Caliò, Svenja Schmidt, Georg Goebel, Fabian Leys, Karoline Radl, Caroline Breitegger, Marjan Arvandi, Alexa Blum, Christoph Gabl and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Tremor in multiple system atrophy: a systematic literature review.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Pooled it
  2. Multimodal Treatment of Neck Pain in Multiple System Atrophy.Movement disorders clinical practice · 2026
    Article
  3. Setting up an autonomic unit within the neurological department: a position statement of the European Federation of Autonomic Societies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  4. Types of Pain in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  5. Clinical utility of digital technologies in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Alessandra FanciulliDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. alessandra.fanciulli@i-med.ac.at.ORCID http://orcid.org/0000-0002-2854-4179
Bianca CaliòDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-8652-2480
Svenja SchmidtDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Georg GoebelEPICENTER - Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-7454-6212
Fabian LeysDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-1714-5305
Karoline RadlDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Caroline BreiteggerDepartment of Health Care Ethics, University of Graz, Graz, Austria.ORCID http://orcid.org/0009-0003-8757-2027
Marjan ArvandiInstitute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT TIROL-University for Health Sciences and Technology, Hall in Tirol, Austria.ORCID http://orcid.org/0000-0002-0976-9479
Alexa BlumDepartment of Psychiatry, Psychotherapy, Psychosomatics, and Medical Psychology, University Clinic of Psychiatry II, Innsbruck Medical University, Innsbruck, Austria.
Christoph GablTyrolean Regional Institute for Integrated Palliative and Hospice Care, Tiroler Hospiz Gemeinschaft, Hall in Tirol, Austria.ORCID http://orcid.org/0009-0009-4383-3284
Oliver GalvanDepartment for Hearing, Speech and Voice Disorders, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-5499-1290
Achim HermsNeuro-Urology Unit, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0009-0005-4416-3930
Birgit HöglDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-1894-7641
Bernhard HolznerInstitute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT TIROL-University for Health Sciences and Technology, Hall in Tirol, Austria.ORCID http://orcid.org/0000-0002-3389-3621
Frank JaguschDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0009-0005-3996-0871
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-9836-2514
Andrea Knoflach-GabisTyrolean Regional Institute for Integrated Palliative and Hospice Care, Tiroler Hospiz Gemeinschaft, Hall in Tirol, Austria.ORCID https://orcid.org/0009-0004-6931-0821
Mariella KoeglDepartment of Neurology, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0009-0002-5769-6195
Igor KuchinInstitute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT TIROL-University for Health Sciences and Technology, Hall in Tirol, Austria.ORCID http://orcid.org/0009-0007-3211-3412
Stefan LorenzlInstitute of Palliative Care, Paracelsus Medical University, Salzburg, Austria.ORCID http://orcid.org/0000-0002-1165-0821
Werner PoeweDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-4367-0971
Sinikka PrajczerTyrolean Regional Institute for Integrated Palliative and Hospice Care, Tiroler Hospiz Gemeinschaft, Hall in Tirol, Austria.ORCID http://orcid.org/0009-0007-8985-8992
Gerhard RumpoldDepartment of Psychiatry, Psychotherapy, Psychosomatics, and Medical Psychology, University Clinic of Psychiatry II, Innsbruck Medical University, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-6037-793X
Andreas SchlagerDepartment of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0009-0003-3540-9877
Anette SchragDepartment of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-9872-6680
Klaus SeppiDepartment of Neurology, Provincial Hospital of Kufstein, Kufstein, Austria.ORCID http://orcid.org/0000-0001-6503-1455
Uwe SiebertInstitute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT TIROL-University for Health Sciences and Technology, Hall in Tirol, Austria.ORCID http://orcid.org/0000-0001-6425-7671
Gudrun SchönherrDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Gaby SroczynskiUniversity Clinic of Psychiatry I, Innsbruck Medical University, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-5193-0492
Martina SchmidhuberDepartment of Health Care Ethics, University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0002-7701-5433
Petra SchwingenschuhNeuro-Urology Unit, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-3294-6824
Beate JahnUniversity Clinic of Psychiatry I, Innsbruck Medical University, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-6764-6362
Florian KrismerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-4493-5073
Gregor K WenningDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-9077-1666

Funding

Austrian Science Fund FG 2700-B
6 · The paper itself

Abstract

Multiple system atrophy (MSA) represents a management challenge due to its variable clinical presentation, and lack of established multidisciplinary care protocols. In advanced stages, physical barriers often prevent access to specialized care, leaving patients and caregivers to face complications and fear alone. This 18-month, monocentric, open-label study evaluates the impact of a personalized, multidisciplinary treatment, integrating mobile palliative care, on the quality of life (QoL, measured by EQ-5D-5L indices) of MSA individuals compared to a matched historical European MSA cohort. Forty-six participants will undergo baseline clinical, psychological, and neuro-rehabilitation assessments, along with an online interview to identify individual healthcare preferences. These assessments will guide personalized therapeutic plans, including palliative care, self-directed physio-, speech, and occupational exercises, based on operational protocols informed by evidence and good clinical practice. Six-, 12-, and 18-month follow-ups will reassess needs and adapt plans to address disease progression and changing preferences, ensuring continuous personalization. Repeated interviews at month-12, phone-calls and satisfaction surveys at month-1, 7, 13, and 18 will monitor compliance, identify barriers, and gather feedback. A subgroup of 23 participants will be block-wise randomized to additionally receive monthly and on-demand telemedicine visits for tailored support. Informal caregivers will join an 18-month observational study assessing their QoL and burden through repeated evaluations, offering insights into evolving challenges. We expect that multidisciplinary, patient-centered care with integrated mobile palliative and telemedicine support helps to warrant continuity of care and improve the QoL of MSA individuals throughout the disease course. Its acceptance, safety, and cost-effectiveness will be also assessed.

Indexed as

Multiple System AtrophyPalliative CarePrecision MedicineTelemedicineFemaleHumansMaleQuality of LifeAdvance care planningCaregiversMultiple system atrophyNeuro-rehabilitationPalliative medicineTelemedicine

Identifiers

PMID40411588
PMCPMC13216168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.