Evidence map›Paper›PMID 40411544›Full record

ArticleDiscover oncology2025

MiR-493-5p functions as a tumour suppressor in head and neck squamous cell carcinoma progression by targeting HIF-1α.

Jiahui Liu, Ruxian Tian, Xi Chen, Qing Song, Caiyu Sun, Dongxian Li, Yuhui Fang, Shijun Lv, Yumei Li, Xicheng Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiahui Liu *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Ruxian Tian *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Xi Chen *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Qing SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yeda Hospital, Yantai, China.
Caiyu SunDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Dongxian LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Yuhui FangDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Shijun LvDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Yumei LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China. myheart1263@163.com.
Xicheng SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China. drxchsong@163.com.

Funding

Shandong Medical Association Clinical Research Fund-Qilu special fund YXH2022ZX02185Taishan Scholar Project of Shandong Province,China No.ts20190991the Key R&D Project of Shandong Province 2022CXPT023
6 · The paper itself

Abstract

backgroundHead and neck squamous cell carcinoma (HNSCC) demonstrates insidious onset, high prevalence, and low 5-year overall survival rate. While downregulation of miR-493-5p is implicated in the development of various cancers, its role in HNSCC remains unclear. Here, we explored the association of miR-493-5p with HNSCC progression and elucidated the underlying mechanisms.

methodsThe miR-493-5p expression in HNSCC tissues and cells was verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell proliferation and migration were detected by Cell Counting Kit 8, colony formation, and wound-healing assay. Dual-luciferase reporter gene assay was used to verify that miR-493-5p targeted hypoxia-inducible factor (HIF)-1α. Cobalt chloride (CoCl

resultsMiR-493-5p expression was low and beneficial to prognosis in HNSCC tumours. MiR-493-5p constrained HNSCC cell proliferation and migration and inhibited HIF-1α expression by targeting its 3' untranslated region directly. CoCl

conclusionsMiR-493-5p, which targets HIF-1α and inhibits glycolysis and EMT, may be a novel therapeutic target for HNSCC.

Indexed as

Head and neck squamous cell carcinomaHIF-1αMigrationMiR-493-5pProliferation

Identifiers

PMID40411544
PMCPMC12103410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.