Evidence map›Paper›PMID 40411303›Full record

Trial reportJournal of diabetes investigation2025

A 90 g/day low-carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial.

Yu-Ting Wang, Chin-Ying Chen, Wei-Sheng Huang, Hui-Chuen Chen, Long-Teng Lee, Chyi-Feng Jan, Hsien-Liang Huang, Jaw-Shiun Tsai

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Ting WangDepartment of Family Medicine, Yunlin Branch, National Taiwan University Hospital, Huwei Township, Yunlin County, Taiwan.
Chin-Ying ChenDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-7827-8764
Wei-Sheng HuangDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.
Hui-Chuen ChenDepartment of Dietetics, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.
Long-Teng LeeDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.
Chyi-Feng JanDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.
Hsien-Liang HuangDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.
Jaw-Shiun TsaiDepartment of Family Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan.

Funding

National Taiwan University Hospital 106-37
6 · The paper itself

Abstract

aimsThis study explored the glycemic control and Fried frailty criteria of a 90 g/day low-carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months.

methodsForty-four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were randomly assigned to a 90 g/day LCD or traditional diabetic diet (TDD). The analysis was performed using an intention-to-treat analysis.

resultsA total of 42 (95.5%) patients completed the trial. The 18-month mean change from baseline was statistically significant for 2-h glucose (-100.0 ± 57.7 vs -18.6 ± 86.2 mg/dL) and waist circumference (-6.3 ± 7.9 vs -1.7 ± 4.7 cm) between the LCD and TDD groups (P < 0.05). The 18-month mean change from baseline was not significantly different in HbA1c (-1.55 ± 1.0 vs -0.97 ± 1.2; P = 0.097). After intervention, the proportions of robust, pre-frailty, and frailty in the TDD and LCD groups were 20.0% vs 13.6%, 75.0% vs 86.4%, and 5.0% vs 0.0%, respectively (P > 0.05).

conclusionsA 90 g/d LCD reflected improved glycemic control with significantly lower waist circumference without decreasing frailty in older patients with type 2 diabetes.

Indexed as

BiomarkersDiabetes Mellitus, Type 2Diet, Carbohydrate-RestrictedFrailtyGlycemic ControlAgedAged, 80 and overBlood GlucoseFemaleFollow-Up StudiesGlycated HemoglobinHumansMalePrognosisBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanDiabetesFrailtyLow‐carbohydrate diet

Identifiers

PMID40411303
PMCPMC12315243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.