ArticleThe Laryngoscope2025
Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions.
Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Myofascial pain and dysfunction as predictors of tinnitus in adults: a case-control study.Head & face medicine · 2026Article
- Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions.The Laryngoscope · 2025Article
- Trajectory of COVID-related tinnitus over the pandemic timeline.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the temporal and bidirectional relationships between tinnitus subtypes-pulsatile tinnitus (PT) and non-pulsatile tinnitus (NPT)-and psychiatric conditions, specifically generalized anxiety disorder (GAD) and major depression (MD).
methodsThis retrospective cohort study utilized data from the TriNetX Research Network, including over 140 million patients. Patients were categorized based on ICD-10 codes for PT, NPT, GAD, and MD. Propensity score matching (PSM) was applied to control for demographic and clinical confounders. Statistical analyses included chi-square tests, odds ratios (OR) with 95% confidence intervals (CIs) to ascertain the statistical significance of temporal associations between tinnitus subtypes and psychiatric conditions.
resultsNPT patients had significantly higher risks of developing GAD and MD than PT patients. PSM analyses confirmed that PT patients had consistently lower risks of developing these conditions, even across treated and untreated subgroups. Among patients with tinnitus, those with PT had significantly higher rates of pre-existing GAD and MD compared to those with NPT.
conclusionNPT is associated with significantly higher risks of developing GAD and MD compared to PT, highlighting a greater psychiatric burden among this subgroup. Conversely, patients with tinnitus who had pre-existing GAD or MD were more likely to have PT than NPT, suggesting a bidirectional relationship. These findings underscore the importance of integrating mental health assessment into tinnitus care and inform future research into subtype-specific management strategies. LEVEL OF EVIDENCE: 3:
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