Evidence map›Paper›PMID 40411205›Full record

SynthesisActa physiologica (Oxford, England)2025

Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Jane Sophie Lauxen, Sonja Vondenhoff, Carolina Victoria Cruz Junho, Philipp Martin, Susanne Fleig, Katharina Schütt, Ulrike Schulze-Späte, Oliver Soehnlein, Leticia Prates-Roma, Yvonne Döring and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jane Sophie LauxenInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0003-4358-9062
Sonja VondenhoffInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0003-6351-2441
Carolina Victoria Cruz JunhoInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Philipp MartinInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Susanne FleigDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Katharina SchüttDepartment of Internal Medicine I-Cardiology, Angiology and Internal Intensive Care Medicine, RWTH Aachen University Hospital, Aachen, Germany.
Ulrike Schulze-SpäteSection of Geriodontics, Department of Conservative Dentistry and Periodontics, University Hospital Jena, Jena, Germany.
Oliver SoehnleinInstitute of Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), University Hospital Münster, University of Münster, Münster, Germany.
Leticia Prates-RomaBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Center for Human and Molecular Medicine (ZHMB), Center for Gender-Specific Biology and Medicine (CGBM), Faculty of Medicine, Saarland University, Homburg, Germany.
Yvonne DöringDivision of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Constance C F M J BaatenInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Heidi NoelsInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0003-3053-6984

Funding

Alexander von Humboldt-StiftungDeutsche ForschungsgemeinschaftDeutsche Stiftung für HerzforschungDeutsches Zentrum für Herz-KreislaufforschungDutch Heart FoundationEuropean Foundation for the Study of DiabetesInterdisciplinary Centre for Clinical Research, Faculty of Medicine, RWTH Aachen UniversityRWTH Aachen, Start-up Funding
6 · The paper itself

Abstract

backgroundPatients with chronic kidney disease (CKD) are at increased cardiovascular risk. Since neutrophils play a central role in atherosclerosis and cardiovascular disease, this study analyzed neutrophil function in CKD patients.

methodsA systematic review of neutrophil function in CKD patients compared to controls was performed according to PRISMA guidelines by searching PubMed and the Web of Science. A meta-analysis summarized the production of reactive oxygen species (ROS) in CKD patients on dialysis in Forest plots. Influencer outlier analyses evaluated risk of bias.

resultsOverall, 92 studies were included, of which 18 in the meta-analysis. Although study heterogeneity was high, the systematic review identified primarily reduced phagocytosis capacity but increased neutrophil degranulation and basal ROS production in neutrophils from CKD patients on hemodialysis compared to controls. Phagocytosis and basal ROS production were mainly unaltered in non-dialysis dependent CKD patients and CKD patients on peritoneal dialysis. The meta-analysis confirmed increased ROS generation in basal conditions predominantly in CKD patients on hemodialysis (Hedges g = 1.20, 95% CI: [0.32; 2.09]), with an insufficient study number for a clear comparison to CKD patients on peritoneal dialysis. However, upon neutrophil stimulation with sterile inflammatory triggers, ROS production was also increased in neutrophils from patients on peritoneal dialysis (Hedges g = 0.89, 95% CI: [0.34; 1.43]).

conclusionIncreased degranulation and basal ROS formation were observed in neutrophils of CKD patients on hemodialysis, which could contribute to their increased cardiovascular risk. Future studies should compare neutrophil activity in patients of different CKD stages and comorbidities also in relation to cardiovascular outcomes.

Indexed as

NeutrophilsRenal Insufficiency, ChronicHumansPhagocytosisReactive Oxygen SpeciesRenal DialysisReactive Oxygen Specieschronic kidney diseaseneutrophilsreactive oxygen species

Identifiers

PMID40411205
PMCPMC12102643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.