Evidence map›Paper›PMID 40410811›Full record

ReviewGut pathogens2025

Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.

Rania G Elbaiomy, Xiaoling Luo, Rong Guo, Shiyuan Deng, Meifang Du, Ahmed H El-Sappah, Mohammed Bakeer, Mahmoud M Azzam, Ahmed A Elolimy, Mahmoud Madkour and 2 more

Abstract readReview
In one paragraph

Review in Gut pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. CurrentJGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  2. Article
  3. Helicobacter pylori eradication in the face of escalating anti-microbial resistance: Geographic heterogeneity and emerging treatment strategies.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  4. Article
  5. Genomic characterization and biological activities of cell-free supernatant fromFrontiers in cellular and infection microbiology · 2026
    Article
  6. Review
  7. Resistance to Clarithromycin and Fluoroquinolones inAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rania G ElbaiomyDepartment of Biological Engineering, Sichuan University of Science & Engineering, Zigong, 643000, China.
Xiaoling LuoDepartment of Gastroenterology, FuShun People's Hospital, Zigong, 643000, China.
Rong GuoDepartment of Gastroenterology, FuShun People's Hospital, Zigong, 643000, China.
Shiyuan DengDepartment of Biological Engineering, Sichuan University of Science & Engineering, Zigong, 643000, China.
Meifang DuDepartment of Biological Engineering, Sichuan University of Science & Engineering, Zigong, 643000, China.
Ahmed H El-SappahSchool of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, 644000, Sichuan, China.
Mohammed BakeerDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, USA.
Mahmoud M AzzamDepartment of Animal Production, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
Ahmed A ElolimyDepartment of Integrative Agriculture, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, Abu Dhabi, 15551, United Arab Emirates. elolimy@uaeu.ac.ae.
Mahmoud MadkourAnimal Production Department, National Research Centre, Dokki, 12622, Giza, Egypt.
Zaixin LiDepartment of Biological Engineering, Sichuan University of Science & Engineering, Zigong, 643000, China. 492747726@qq.com.
Zhi ZhangDepartment of Biological Engineering, Sichuan University of Science & Engineering, Zigong, 643000, China. zhangzhi@suse.edu.cn.

Funding

Natural Science Foundation of Sichuan University of Science and Engineering 2021RC29Sichuan Province Science and Technology Support Program 2023NSFSC0586
6 · The paper itself

Abstract

The identification of Helicobacter pylori (H. pylori) infection as the primary etiology of gastroduodenal diseases represents a significant advancement in the field of gastroenterology. The management of these diseases has undergone a substantial transformation, and antibiotic treatment is now universally applicable. H. pylori has been the subject of numerous investigations to determine the prevalence of antibiotic resistance. However, many of these studies are limited, particularly regarding the number and representativeness of the strains assessed. Genetic and physiological modifications, such as gene mutations, efflux pump alterations, biofilm formation, and coccoid formation, contribute to the observed resistance. Our review focuses on the emergence of antibiotic-resistant strains, particularly emphasizing the various modifications of H. pylori that confer this resistance. In conclusion, we elucidate the challenges, potential solutions, and prospects in this field, providing researchers with the knowledge necessary to overcome the resistance exhibited by H. pylori.

Indexed as

BiofilmClarithromycinEfflux pump systemsH. pyloriPenicillinResistance

Identifiers

PMID40410811
PMCPMC12102891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.