ArticleBMC oral health2025
Association between human cytomegalovirus infection and incidence of severe orofacial clefts: a series of rare cases.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Maternal periodontitis and orofacial clefts: Evidence and treatment.Journal of Indian Society of PeriodontologyArticle
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1 author.
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Abstract
BACKGROUND/
objectivesHuman cytomegalovirus (HCMV) infection was scarcely reported as a prejudicing factor of CLP incidence. The aim of this study is to report an association between HCMV infection and incidence of severe orofacial clefts. MATERIALS/
methodsFive infants with severe orofacial clefts were included in the current study. One of the infants is with an oblique facial cleft extended to the left orbit and associated with missing left eyeball. Another infant was with facial cleft extending downward resulting in a clefted lower lip, clefted mandible and clefted tongue. All the patients' mothers were evaluated for the amount of HCMV IgG in blood samples.
resultsAll the five mothers of the included infants had a positive HCMV IgG results in the collected blood samples with the value of 908.8 (± 400.6). The amount of HCMV IgG was higher in cases with more severe clinical presentation. LIMITATIONS: Due to the rarity of cases with severe orofacial clefts, only 5 patients were included. Lake of genetic data and control group are another limitations.
conclusionWithin the limitation of the rareness of cases with severe orofacial clefts, HCMV infection to mothers before or during pregnancy might be a predisposing factor of incidence of severe orofacial clefts.
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