Evidence map›Paper›PMID 40410723›Full record

Trial reportBMC cancer2025

Effects of individualized PEEP on pulmonary function, cerebral blood flow and postoperative cognitive function in patients undergoing laparoscopic radical resection of rectal cancer.

Xiaoyan Zhang, Jingjing Zhang, Caixia Zhao, Yichao Cai, Qing Yang, Caixia Yue, Kan Li

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyan Zhang *Department of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Jingjing Zhang *Department of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Caixia ZhaoDepartment of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Yichao CaiDepartment of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Qing YangDepartment of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Caixia YueDepartment of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China.
Kan LiDepartment of Anesthesiology, Zhangjiakou First Hospital, Operating Room, 6th floor, Building 4, No.6, Libai Si Lane, Xinhua Qian Street, Qiaoxi District, Zhangjiakou City, 075061, Hebei Province, China. likan202310@163.com.

Funding

Zhangjiakou City 2023 Municipal Science and Technology Plan Self funded Project 2322089DZhangjiakou City 2023 Municipal Science and Technology Plan Self raised Fund Project 2322185D
6 · The paper itself

Abstract

objectiveTo evaluate the effects of individualized PEEP on pulmonary function, cerebral blood flow, and postoperative cognitive function in patients undergoing laparoscopic radical resection of rectal cancer.

methods100 patients who underwent laparoscopic radical rectal cancer surgery at our hospital between August 2021 and May 2023 were randomized into two groups: the DP group (optimal PEEP group oriented to driving pressure) and the Cdyn group (optimal PEEP group oriented to pulmonary compliance). Anesthesia was induced in both groups with 0.3 mg/kg of remizolam + 0.15 mg/kg of CIS atracurium + 0.5 ug/kg of sufentanil. Lung ultrasound score (LUS), peak and plateau airway pressures (PEAK, PLAT), oxygenation index (OI), driving pressure (DP), and pulmonary dynamic compliance (Cdyn) were measured at different time points. Cerebral blood flow and cognitive function were also assessed. T

resultsThere were no significant differences in general information between the two groups, P > 0.05. Compared with the DP group, the Cdyn group had lower LUS at T

conclusionPEEP guided by lung compliance improves pulmonary function, cerebral blood flow, and cognitive function, offering clinical benefits.

Indexed as

Cerebrovascular CirculationCognitionLaparoscopyLungPositive-Pressure RespirationRectal NeoplasmsAdultAgedFemaleHumansLung ComplianceMaleMiddle AgedPostoperative PeriodRespiratory Function TestsCerebral blood flowCognitive functionIndividualized peepLaparoscopic radical resection of rectal cancerPulmonary function

Identifiers

PMID40410723
PMCPMC12100997

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.