ArticleEuropean radiology experimental2025
7-T MRI-based surrogate for histopathology examination of liver fibrosis.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Inflammatory and resolution stages of hepatic injury: imaging with USPIO-enhanced MRI in mice.European radiology experimental · 2026Article
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10 authors.
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Abstract
backgroundTo demonstrate that 7-T magnetic resonance imaging (MRI) provides a surrogate for histopathology of fresh ex vivo liver tissue, using the case study of liver fibrosis.
methodsWe prospectively enrolled 20 patients undergoing surgical liver resection between November 2021 and April 2023. Each ex vivo fresh liver tissue specimen (~ 1 cm
resultsFive patients were excluded from the final analysis (one patient due to poor specimen quality, two due to surgery cancellation, and two previously published used for reader training). Of the remaining 15 patients, 10 (67%) presented with chronic liver diseases and 8/15 (53%) with advanced (F3 or F4) fibrosis. Radiologists achieved 88% sensitivity, 100% specificity, 93% accuracy (95% confidence interval 68-100%) and 0.94 Harrell's c-index (0.86-1.00). Pathologists achieved 88% sensitivity, 86% specificity, 87% accuracy (60-98%) and 0.87 Harrell's c-index (0.74-0.99). There were no statistically significant differences between MRI-based and pathologic reference standard stage (p ≥ 0.655).
conclusionWith an in-plane spatial resolution of ~ 75 × 75 µm RELEVANCE STATEMENT: 7-T MRI provides a surrogate for histopathology visualisation of fresh ex vivo liver tissue, opening new research perspectives for clinical high-field MRI of the liver. KEY POINTS: Using the newly developed MRI-METAVIR score, 7-T MRI data strongly correlated with histopathology, achieving excellent agreement and accuracy. 7-T MRI accurately differentiated advanced from minimal liver fibrosis. 7-T MRI visualises liver micro-architecture, enabling pathology-like, noninvasive three-dimensional imaging.
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