Evidence map›Paper›PMID 40410447›Full record

ArticleCommunications biology2025

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution.

Falko Fuhrmann, Felix C Nebeling, Fabrizio Musacchio, Manuel Mittag, Stefanie Poll, Monika Müller, Eleonora Ambrad Giovannetti, Michael Maibach, Barbara Schaffran, Emily Burnside and 10 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Falko Fuhrmann *Neuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Felix C Nebeling *Neuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Fabrizio Musacchio *Neuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Manuel MittagNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Stefanie PollNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-5301-2791
Monika MüllerNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Eleonora Ambrad GiovannettiNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0003-0420-154X
Michael MaibachNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Barbara SchaffranAxon Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Emily BurnsideAxon Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0003-3238-0602
Ivy Chi Wai ChanDynamics of Neuronal Circuits Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-0261-1900
Alex Simon LagurinDynamics of Neuronal Circuits Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Nicole ReichenbachVascular Neurology Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Sanjeev KaushalyaCore Research Facilities and Services, Light Microscope Facility, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Hans FriedCore Research Facilities and Services, Light Microscope Facility, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Stefan LindenDepartment of Physics, Nanophotonics, University of Bonn, Bonn, Germany.
Gabor C PetzoldVascular Neurology Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-0145-8641
Gaia TavosanisDynamics of Neuronal Circuits Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-8679-5515
Frank BradkeAxon Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-0345-3772
Martin FuhrmannNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. martin.fuhrmann@dzne.de.ORCID http://orcid.org/0000-0001-7672-2913

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1089, C01, B06Deutsche Forschungsgemeinschaft (German Research Foundation) SPP2395EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) MicroSynCom865618
6 · The paper itself

Abstract

The medial prefrontal cortex (mPFC) is important for higher cognitive functions, including working memory, decision making, and emotional control. In vivo recordings of neuronal activity in the mPFC have been achieved via invasive electrical and optical approaches. Here we apply low invasive three-photon in vivo imaging in the mPFC of the mouse at unprecedented depth. Specifically, we measure neuronal and astrocytic Ca

Indexed as

Microscopy, Fluorescence, MultiphotonNeurogliaNeuronsPrefrontal CortexAnimalsCalciumDendritic SpinesMaleMiceMice, Inbred C57BLCalcium

Identifiers

PMID40410447
PMCPMC12102176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.