Evidence map›Paper›PMID 40410349›Full record

ArticleScientific reports2025

Far-ultraviolet light causes direct DNA damage in human lung cells and tissues.

Asta Valanciute, Calum A Ross, Alex Burden, Syam Mohan P C Mohanan, Mohammed Sabbah, Jessica M W Ghobrial, Stuart Dickson, Hui Xin Loh, Elvira Williams, Aysha Ali and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Asta ValanciuteCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. Asta.Valanciute@ed.ac.uk.
Calum A RossInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, UK.
Alex BurdenCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Syam Mohan P C MohananCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Mohammed SabbahInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, UK.
Jessica M W GhobrialCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Stuart DicksonCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Hui Xin LohCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Elvira WilliamsCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Aysha AliCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Christian BrahmsInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, UK.
Ahsan R AkramCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Lynn PatersonInstitute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, UK.
Natalie K JonesCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Bethany MillsCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
John C TraversInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, UK.
Robert R ThomsonInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, UK. R.R.Thomson@hw.ac.uk.
Kevin DhaliwalCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. Kev.Dhaliwal@ed.ac.uk.

Funding

the Engineering and Physical Sciences Research Council (EPSRC) EP/T020903/1; EP/S025987/1the European Research Council under the European Union Horizon 2020 Research and Innovation program: Proof of Concept Grant agreement ULIGHT 899900the Royal Academy of Engineering through Research Fellowship RF/202122/21/133
6 · The paper itself

Abstract

Far-ultraviolet C (Far-UVC) radiation, with a wavelength range from 200 to 235 nm, is germicidal and holds potential for clinical applications. However, its use against deep-seated and internal infections, such as those affecting the lungs, remains less well established. The safety profile of Far-UVC irradiation requires further investigation across different human tissues. In this study, we utilised a krypton-chloride excimer lamp and a pulsed laser system to examine the effects of Far-UVC irradiation on human lung cells in vitro and primary human tracheal tissue. Primary human tracheal tissue and cells exposed to continuous wave (222 nm) and pulsed 206 nm and 222 nm light at doses of 5, 25, and 50 mJ/cm

Indexed as

DNA DamageLungTracheaUltraviolet RaysCell SurvivalEpithelial CellsHistonesHumansPhosphorylationH2AX protein, humanHistones206 nm222 nm(6-4) PPCell deathDNA damageFar-UVCH2AX(Ser139)Human lung cells

Identifiers

PMID40410349
PMCPMC12102315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.