Evidence map›Paper›PMID 40410331›Full record

ArticleEuropean radiology2026

Imaging in staging, treatment planning, and monitoring of hepatocellular carcinoma for local and locoregional therapies: consensus recommendations from EORTC and ESGAR.

Osman Öcal, Christoph Johannes Zech, Maria Antonietta Bali, David Pasquier, Felix Mottaghy, Ingo Einspieler, Nikolaos Kartalis, Irene Bargellini, Roberto Iezzi, Timm Denecke and 9 more

Erratum issuedAbstract readConsensus Statement
In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Osman ÖcalDepartment of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany. osman.oecal@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-5234-1921
Christoph Johannes ZechRadiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Maria Antonietta BaliEuropean Society of Gastrointestinal and Abdominal Radiology (ESGAR), Vienna, Austria.
David PasquierImaging Group, European Organisation of Research and Treatment in Cancer (EORTC), Brussels, Belgium.
Felix MottaghyDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Ingo EinspielerDepartment of Radiology, University Hospital Regensburg, Regensburg, Germany.
Nikolaos KartalisEuropean Society of Gastrointestinal and Abdominal Radiology (ESGAR), Vienna, Austria.
Irene BargelliniDiagnostic and Interventional Radiology Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.
Roberto IezziDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radiologia d'Urgenza e Interventistica, Roma, Italia.
Timm DeneckeDepartment of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Wolfgang Gerhard KunzImaging Group, European Organisation of Research and Treatment in Cancer (EORTC), Brussels, Belgium.
Bernhard GebauerDepartment of Radiology, Charité-University Medicine Berlin, Berlin, Germany.
Henning WegeCancer Center Esslingen, Klinikum Esslingen, Esslingen, Germany.
Roberto CannellaSection of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy.
Daniela Elena Oprea-LagerImaging Group, European Organisation of Research and Treatment in Cancer (EORTC), Brussels, Belgium.
Arndt VogelDivision of Gastroenterology and Hepatology, Toronto General Hospital, Toronto, ON, Canada; Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Bruno SangroLiver Unit and HPB Oncology Area, Clínica Universidad de Navarra and CIBEREHD, Pamplona, Spain.
Max SeidenstickerImaging Group, European Organisation of Research and Treatment in Cancer (EORTC), Brussels, Belgium.
study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriinterventional imaging of patients with hepatocellular carcinoma (HCC) during local and locoregional therapies plays a crucial role in clinical outcome by guiding treatment allocation, planning, and application. However, there is a considerable variety in clinical routine in terms of timing, modality, and imaging protocols. This study aimed to guide the standardization of the imaging procedures for patients with HCC by conducting a Delphi consensus-finding survey.

methodsA multidisciplinary, multinational survey was conducted to standardize the imaging of patients with HCC using the Delphi method.

resultsUnder the guidance of the European Organisation for Research and Treatment of Cancer (EORTC) Imaging and Gastrointestinal Tract Cancer Groups and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR), the recommendations for imaging before, during, and after thermal ablation, transarterial chemoembolization, radioembolization, and stereotactic body radiation therapy were established.

conclusionThis consensus protocol provides a foundational guide for imaging in the daily clinical management of HCC patients, as well as for prospective studies assessing local and locoregional therapies. KEY POINTS: Question There are clear recommendations for the respective therapies/disease stages in HCC, but only to a limited extent for all-around imaging of local therapies. Findings This study conveyed a Delphi consensus-finding survey amongst European experts from multiple medical fields to standardize the periinterventional imaging of HCC patients. Clinical relevance These recommendations can guide both daily clinical practice and prospective trials focused on local and locoregional therapies.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsChemoembolization, TherapeuticDelphi TechniqueEuropeHumansNeoplasm StagingAblationHepatocellular carcinomaImagingSBRTTACE

Identifiers

PMID40410331
PMCPMC12712117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.