Evidence map›Paper›PMID 40410310›Full record

ArticleScientific reports2025

Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity.

Koangyong Sung, Kenji Hosoya, Tatsuya Deguchi, Koya Yamashita, Sangho Kim, Takafumi Sunaga, Hironobu Yasui, Osamu Inanami, Masahiro Okumura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koangyong SungLaboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Kenji HosoyaVeterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. whitelittlesnow@aol.com.
Tatsuya DeguchiVeterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Koya YamashitaLaboratory of Radiation Biology, Department of Applied Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Sangho KimLaboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Takafumi SunagaLaboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Hironobu YasuiLaboratory of Radiation Biology, Department of Applied Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Osamu InanamiLaboratory of Radiation Biology, Department of Applied Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Masahiro OkumuraLaboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Funding

Japan Society for the Promotion of Science 20K06424Japan Society for the Promotion of Science 20K15655
6 · The paper itself

Abstract

Radio-resistance of cancer stem-like cells (CSCs) is associated with the failure of radiation therapy. ZsGreen1-positive (ZsG⁺) cells, which exhibit low proteasome activity, have been used to enable the detection and isolation of CSCs. However, the mechanisms of radio-resistance in canine tumor cells with low proteasome activity remain unclear. This study aimed to elucidate the radio-resistance mechanisms of ZsG

Indexed as

GlutathioneNeoplastic Stem CellsProteasome Endopeptidase ComplexRadiation ToleranceAnimalsCell Line, TumorDogsOxidation-ReductionReactive Oxygen SpeciesSulfasalazineGlutathioneProteasome Endopeptidase ComplexReactive Oxygen SpeciesSulfasalazineCancer stem-like cellsCanine tumorGlutathioneRadio-resistanceReactive oxygen species.

Identifiers

PMID40410310
PMCPMC12102148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.