Evidence map›Paper›PMID 40410264›Full record

ArticleScientific reports2025

Potential predictors of awake surgery failure for insular glioma.

Shigeki Takada, Etsuko Yamamoto Hattori, Noritaka Sano, Masahiro Sawada, Masahiro Tanji, Yohei Mineharu, Takayuki Kikuchi, Yoshiki Arakawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shigeki TakadaDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. takashige826@kuhp.kyoto-u.ac.jp.
Etsuko Yamamoto HattoriDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Noritaka SanoDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Masahiro SawadaDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Masahiro TanjiDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Yohei MineharuDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Takayuki KikuchiDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Yoshiki ArakawaDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To accomplish maximal safe resection for insular glioma (IG), we perform awake surgery (AS) for IG. The aim of our study was to identify potential predictors of AS failure for IG. We retrospectively reviewed the records of 24 patients with IGs who underwent resection between January 2014 and April 2024. Their baseline characteristics and clinical outcomes were examined and we analysed the factors associated with AS failure. AS was planned and performed successfully in 13 cases (the AS group). In five cases, AS was planned but failed due to sleepiness or delayed awakening. AS was not planned in six cases. These 11 cases were assigned to the non-AS (NAS) group. The median extent of tumor resection was 87.7% in the AS group vs. 58.0% in the NAS group (p = 0.004). There were no cases with postoperative permanent neurological deficits in both groups. Basal ganglionic involvement, which means the high-intensity area on Fluid Attenuated Inversion Recovery imaging is found in the basal ganglia consisting of the striatum and globus pallidus, was significantly associated with AS failure. AS contributes significantly to the maximal resection of IG. Basal ganglionic involvement is a potential predictor of AS failure for IG.

Indexed as

Brain NeoplasmsCerebral CortexGliomaNeurosurgical ProceduresWakefulnessAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTreatment FailureTreatment OutcomeAwake surgeryAwake surgery failureBasal ganglionic involvementInsular gliomaPredictor

Identifiers

PMID40410264
PMCPMC12102373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.