Evidence map›Paper›PMID 40410257›Full record

ArticleScientific reports2025

Nonmass lesions on preoperative MRI in breast cancer patients: clinical implications and prognostic significance.

Joon Suk Moon, Tae Kyung Yoo, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sae Byul Lee

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Joon Suk MoonDepartment of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Tae Kyung YooDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Jisun KimDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Il Yong ChungDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Beom Seok KoDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Hee Jeong KimDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Jong Won LeeDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Byung Ho SonDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Sae Byul LeeDivision of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea. newstar153@hanmail.net.ORCID http://orcid.org/0000-0002-3370-6937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the clinical importance and prognostic value of nonmass lesions (NMLs) identified via preoperative magnetic resonance imaging (MRI) in patients with breast cancer, with an emphasis on understanding how these lesions affect treatment decisions and survival outcomes. A retrospective analysis was conducted on 6971 patients diagnosed with breast cancer who underwent surgery at Asan Medical Center, Seoul, between January 2000 and December 2021. Patients were categorized based on the presence or absence of NMLs on preoperative MRI. Various clinicopathological parameters were compared, and survival outcomes, such as overall survival (OS), distant metastasis-free survival (DMFS), regional recurrence-free survival (RFS), and local recurrence-free survival (LFS), were analyzed using Kaplan-Meier and Cox regression methods. Subgroup analyses were performed based on the type of surgery and the administration of neoadjuvant chemotherapy and adjuvant radiation therapy. Of the total cohort, 21.9% (n = 1524) had NMLs. The presence of NMLs was associated with a significant improvement in OS (P = 0.017) for the entire patient group. Multivariate analysis revealed the presence of NMLs as a favorable prognostic factor (hazard ratio 0.47, 95% confidence intervals 0.25-0.90, P = 0.022). Subgroup analyses demonstrated significantly improved OS, DMFS, and RFS outcomes for patients with NMLs who underwent mastectomy after neoadjuvant chemotherapy. NMLs on preoperative MRI in patients with breast cancer are associated with improved overall survival (OS) and serve as an independent prognostic factor. However, further research is needed to elucidate the underlying reasons for these outcomes.

Indexed as

Breast NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHumansKaplan-Meier EstimateMastectomyMiddle AgedNeoadjuvant TherapyPreoperative CarePrognosisRetrospective StudiesBreast cancerMastectomyMRINeoadjuvant chemotherapyNonmass lesionRadiation therapy

Identifiers

PMID40410257
PMCPMC12102365

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