Evidence map›Paper›PMID 40410244›Full record

ArticleNPJ genomic medicine2025

Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children.

Yuyao Wang, Yuzhou Zhang, Haoyu Chen, Xiu Juan Zhang, Riping Zhang, Tsz Kin Ng, Jenson A Tham, Ka Wai Kam, Pancy O S Tam, Alvin L Young and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ genomic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. IMI-Myopia Genetics Report.Investigative ophthalmology & visual science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuyao Wang *Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Yuzhou ZhangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0001-8515-3388
Haoyu ChenJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.ORCID http://orcid.org/0000-0003-0676-4610
Xiu Juan ZhangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Riping ZhangJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Tsz Kin NgJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Jenson A ThamDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Ka Wai KamDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Pancy O S TamDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Alvin L YoungDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-4365-3218
Yingying WeiDepartment of Statistics, The Chinese University of Hong Kong, Hong Kong, China.
Mingzhi ZhangJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Clement C ThamDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Jason C Yam *Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. yamcheuksing@cuhk.edu.hk.
Li Jia Chen *Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. lijia_chen@cuhk.edu.hk.ORCID http://orcid.org/0000-0003-3500-5840

Funding

Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 05160836Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 07180256Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 10210236National Natural Science Foundation of China (National Science Foundation of China) 82171089
6 · The paper itself

Abstract

To identify novel genetic loci for children refractive error, we performed a meta-analysis of two genome-wide association studies (GWASs) of spherical equivalent (SE) in 1,237 children from the population-based Hong Kong Children Eye Study (HKCES) and the Low Concentration Atropine for Myopia Progression (LAMP) study. Replication was conducted in 4,093 Chinese children and 1,814 Chinese adults. Four lead-SNPs (MIR4275 rs292034, TENM3 rs17074027, LOC101928911 rs6925312 and FAM135B rs4609227) showed genome-wide significant association (P ≤ 5.0 × 10

Identifiers

PMID40410244
PMCPMC12102314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.