Evidence map›Paper›PMID 40410231›Full record

Articlenpj aging2025

Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors.

Kavita M Dhodapkar, Sharon Castellino, Shivani Kapadia, Maryam I Azeem, Ava Horvat, Taylor Lawrence, Deborah DeRyckere, Madhav V Dhodapkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kavita M DhodapkarDivision of Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, WA, USA. kdhodapk@fredhutch.org.
Sharon CastellinoAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Shivani KapadiaDepartment of Hematology/Medical Oncology, Emory University, Atlanta, GA, USA.
Maryam I AzeemDepartment of Hematology/Medical Oncology, Emory University, Atlanta, GA, USA.
Ava HorvatDepartment of Hematology/Medical Oncology, Emory University, Atlanta, GA, USA.
Taylor LawrenceAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Deborah DeRyckereAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Madhav V DhodapkarDivision of Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, WA, USA.

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
HARNESSING HOST RESPONSE TO PREVENT MYELOMAR35CA197603 · NCI · YALE UNIVERSITY · PI DHODAPKAR, MADHAV V · 2016 to 2022
$5.8M
B cells in autoimmunity following checkpoint blockade therapyR01CA238471 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, KAVITA MADHAV, SANZ, IGNACIO E. · 2019 to 2023
$2.3M
B cell depletion to prevent autoimmunityR01AR077926 · NIAMS · EMORY UNIVERSITY · PI DHODAPKAR, KAVITA MADHAV, SANZ, IGNACIO E. · 2020 to 2023
$1.6M
Leukemia and Lymphoma Society SCORNCI NIH HHS P30 CA138292NCI NIH HHS R01 CA238471NCI NIH HHS R35 CA197603NIAMS NIH HHS R01 AR077926NIH HHS NIH CA238471NIH HHS R35CA197603
6 · The paper itself

Abstract

We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.

Identifiers

PMID40410231
PMCPMC12102316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.