Evidence map›Paper›PMID 40410198›Full record

ArticleScientific reports2025

Heterozygous interferon signaling deficient mice as animal models for Chikungunya virus infection in the heart.

Shazeed-Ul Karim, Farzana Nazneen, Prince M D Denyoh, David S Bai, Damian G Romero, Fengwei Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shazeed-Ul KarimCell and Molecular Biology Program, School of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, 118 College Drive # 5018, Hattiesburg, MS, 39406, USA.
Farzana NazneenCell and Molecular Biology Program, School of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, 118 College Drive # 5018, Hattiesburg, MS, 39406, USA.
Prince M D DenyohCell and Molecular Biology Program, School of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, 118 College Drive # 5018, Hattiesburg, MS, 39406, USA.
David S BaiOak Grove High School, Hattiesburg, MS, 39402, USA.
Damian G RomeroDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Fengwei BaiCell and Molecular Biology Program, School of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, 118 College Drive # 5018, Hattiesburg, MS, 39406, USA. fengwei.bai@usm.edu.

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
Adrenal cell ATP1A1 mutations and mechanisms of aldosterone biosynthesisR01HL144847 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2019 to 2022
$1.3M
A novel live-attenuated Zika vaccine with a modified 5'UTRR15AI178654 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI BAI, FENGWEI · 2023 to 2023
$444k
American Heart Association 23AIREA1051360National Institute of Allergy and Infectious Diseases 1R15AI178654-01NHLBI NIH HHS R01 HL144847NHLBI NIH HHS R01HL144847NIAID NIH HHS R15 AI178654NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM121334NIGMS NIH HHS P20GM121334
6 · The paper itself

Abstract

Although chikungunya virus (CHIKV)-caused cardiovascular diseases are frequently reported in clinics, the underlying mechanisms are poorly understood, which is primarily due to a lack of animal models. In this study, we report that CHIKV infection in homozygous interferon α/β receptor-deficient (ifnar1

Indexed as

Chikungunya FeverChikungunya virusInterferonsReceptor, Interferon alpha-betaSignal TransductionAnimalsConnective Tissue Growth FactorDisease Models, AnimalHeartHeterozygoteMiceMice, Inbred C57BLMice, KnockoutMyocardiumReceptors, InterferonViral LoadCCN2 protein, mouseConnective Tissue Growth FactorIfnar1 protein, mouseInterferonsReceptor, Interferon alpha-betaReceptors, InterferonChikungunya virusHeartInterferon signaling deficientMiceMyocarditis

Identifiers

PMID40410198
PMCPMC12102211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.