ArticleNature communications2025
New information triggers prospective codes to adapt for flexible navigation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Entorhinal cortex represents task-relevant remote locations independently of CA1.Nature neuroscience · 2026Article
- The Hippocampus Rapidly Integrates Sequence Representations During Novel Multistep Predictions.bioRxiv : the preprint server for biology · 2025Article
- Goal-specific hippocampal inhibition gates learning.Nature · 2025Article
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6 authors.
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Abstract
Navigating a dynamic world requires rapidly updating choices by integrating past experiences with new information. In hippocampus and prefrontal cortex, neural activity representing future goals is theorized to support navigational planning. However, it remains unknown how prospective goal representations incorporate new, pivotal information. Accordingly, we designed a navigation task that precisely introduces new information using virtual reality, and we recorded neural activity as male mice flexibly adapted their planned destinations. Here we show that new information triggered increased hippocampal prospective representations of both possible goals; while in prefrontal cortex, new information caused prospective representations of choices to rapidly shift to the new choice. When mice did not adapt, prefrontal choice codes failed to switch. Prospective codes were dependent on the amount of behavioral adaptation needed; the new goal arm was represented more strongly when animals needed to change their behavior more. Thus, we show how prospective codes update with new information to flexibly adapt ongoing navigational plans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.