Evidence map›Paper›PMID 40410152›Full record

ArticleNature communications2025

Stomata-targeted nanocarriers enhance plant defense against pathogen colonization.

Suppanat Puangpathumanond, Heng Li Chee, Cansu Sevencan, Xin Yang, On Sun Lau, Tedrick Thomas Salim Lew

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suppanat PuangpathumanondDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Heng Li CheeInstitute of Materials Research and Engineering, Agency of Science, Technology and Research, Singapore, Singapore.
Cansu SevencanDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5786-1942
Xin YangDepartment of Biological Sciences, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0003-1706-6287
On Sun LauDepartment of Biological Sciences, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8121-235X
Tedrick Thomas Salim LewDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore. tedrick@nus.edu.sg.ORCID http://orcid.org/0000-0002-4815-9921

Funding

National Research Foundation Singapore (National Research Foundation-Prime Minister's office, Republic of Singapore) NRF-NRFF15-2023-0002
6 · The paper itself

Abstract

Plant pathogens significantly threaten food security and agricultural sustainability, with climate change expected to exacerbate outbreaks. Despite these growing threats, current agrochemical delivery remains untargeted and inefficient. In this study, we develop surface ligand-engineered nanoparticles for targeted delivery to stomata (SENDS), a nanocarrier system designed to target stomatal guard cells, which serve as key pathogen entry points into the plant apoplast. Our approach employs rational ligand engineering of porous nanoparticles, optimizing ligand orientation for efficient stomata targeting across different plant species. Foliar application of SENDS encapsulating an antimicrobial plant alkaloid reduces colonization of Xanthomonas campestris, a major crop pathogen, by 20-fold compared to untargeted nanocarriers. Quantitative assessment of stomatal aperture movement and photosynthetic performance confirms that SENDS enhance plant defense against invading pathogens without disrupting natural stomatal function. This nanobiotechnology approach provides a targeted strategy to improve plant disease resistance, offering new insights into nanocarrier design for more resilient and sustainable agriculture.

Indexed as

NanoparticlesPlant DiseasesPlant StomataXanthomonas campestrisDisease ResistanceDrug CarriersPhotosynthesisDrug Carriers

Identifiers

PMID40410152
PMCPMC12102249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.