Evidence map›Paper›PMID 40409854›Full record

ArticleJACC. Case reports2025

Ischemic Heart Disease in Liver Transplant Candidates With High Bleeding Risk: Any Way Out?

Chiara Del Carlo, Lorenza Santoni, Iacopo Fabiani, Michele Coceani, Chiara Arzilli, Claudio Passino, Paola Carrai, Davide Ghinolfi, Giandomenico Luigi Biancofiore, Michele Emdin

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiara Del CarloDepartment of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: chiara.delca6@gmail.com.
Lorenza SantoniDepartment of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: lorenzasantoni93@gmail.com.
Iacopo FabianiCardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Michele CoceaniCardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Chiara ArzilliCardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Claudio PassinoCardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.
Paola CarraiHepatobiliary Surgery and Liver Transplantation Unit, University of Pisa, Medical School and Hospital, Pisa, Italy.
Davide GhinolfiHepatobiliary Surgery and Liver Transplantation Unit, University of Pisa, Medical School and Hospital, Pisa, Italy.
Giandomenico Luigi BiancofioreTransplant ICU Department, Pisa University Hospital, Pisa, Italy.
Michele EmdinCardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease in candidates for liver transplantation is a real challenge because of the need to balance the risks of bleeding and thrombosis. Antiplatelet therapy, essential to prevent thrombotic events, may increase the risk of hemorrhagic complications, especially in the context of hepatic surgery. A 71-year-old woman with end-stage liver disease (ESLD) presented for a pretransplantation evaluation. She received a diagnosis of significant coronary artery disease (CAD), and a multidisciplinary discussion resulted in the option for an invasive treatment with several precautions to minimize her bleeding risk. Because of the intricacy of underlying comorbidities and the elevated perioperative risk, managing CAD in patients with ESLD is particularly challenging. More research and evidence are needed on treating CAD in this patient group. Patients with ESLD who are waiting for liver transplantation should have CAD actively screened. Multidisciplinary treatment is crucial to maximizing the results.

Indexed as

antiplateletdrug-coated balloonmyocardial revascularizationpercutaneous coronary intervention

Identifiers

PMID40409854
PMCPMC12243045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.