Evidence map›Paper›PMID 40409739›Full record

ArticleRespiratory medicine2025

Spirometric pattern transitions in a World Trade Center occupational cohort on longitudinal surveillance.

Jonathan Weber, Zitong Zhang, John T Doucette, Akshay Sood, Juan C Celedón, Rafael E de la Hoz

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03295279 (Pulmonary Diseases in WTC Workers), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03295279 enrolling by invitationnot on this map

Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2012 to 2027Enrolled2,122ConditionsChronic Airway Disease, Interstitial Lung Disease, Lung Cancer
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan WeberDeMatteis Cardiovascular Institute, St. Francis Hospital & Heart Center, Roslyn, NY, USA. Electronic address: Jonathan.Weber@icahn.mssm.edu.
Zitong ZhangDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Zitong.Zhang@mssm.edu.
John T DoucetteDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: John.Doucette@mssm.edu.
Akshay SoodDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA. Electronic address: ASood@salud.unm.edu.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: Juan.Celedon@chp.edu.
Rafael E de la HozDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Rafael.delaHoz@mssm.edu.

Funding

NIOSH CDC HHS U01 OH011697
6 · The paper itself

Abstract

backgroundMany workers and volunteers who participated in the rescue and recovery of the World Trade Center (WTC) disaster site in 2001-2002 manifest a heterogeneous group of chronic lower airway diseases, with variable spirometric patterns on longitudinal surveillance. We examined systematically the observed transitions among those spirometric patterns and assessed their association with BMI and occupational WTC exposure intensity.

methodsWe selected 10,810 Mount Sinai WTC General Responders' Cohort members with at least three acceptable quality periodic spirometries (n = 56,312) performed between July 2002 and November 2019. We defined three spirometric patterns: (1) normal: prebronchodilator first-second forced expiratory volume (FEV

resultsLow FVC is the most frequent abnormal spirometric pattern in the WTC workers. Substantial stationary probabilities of stability (0.88) were observed for normal, and less so for low FVC (0.73) and obstructive (0.65) pattern. At least 80 % of the observed transitions involved the normal and low FVC patterns, and both higher WTC exposure intensity (early arrival at the site), and body mass index (BMI) were predictors of transitions to low FVC in this cohort.

conclusionLow FVC is relatively stable, and both WTC exposure intensity and BMI are independently and significantly associated with transitions to it. Transitions to obstruction are generally infrequent among the WTC workers and have greater instability.

Indexed as

Emergency RespondersOccupational DiseasesOccupational ExposureSeptember 11 Terrorist AttacksSpirometryAdultBody Mass IndexCohort StudiesFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedNew York CityRescue Work2001AsthmaChronic obstructive pulmonary diseaseCohort studyInhalation injuryOccupational healthOccupational medicineWorld Trade Center attack

Identifiers

PMID40409739
PMCPMC13197207

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.