Evidence map›Paper›PMID 40408638›Full record

ArticleACS infectious diseases2025

SerpinB3/Protease Activated Receptor-2 Axis Is Essential for SARS CoV-2 Infection.

Ilaria Frasson, Santina Quarta, Mariagrazia Ruvoletto, Alessandra Biasiolo, Monica Chinellato, Cristian Turato, Maristella Maggi, Laura Cendron, Sara N Richter, Patrizia Pontisso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaria FrassonDepartment of Molecular Medicine, University of Padua, via Gabelli 63, 35128 Padua, Italy.ORCID 0000-0001-5135-5707
Santina QuartaDepartment of Medicine, University of Padua, via Giustiniani, 2, 35128 Padua, Italy.
Mariagrazia RuvolettoDepartment of Medicine, University of Padua, via Giustiniani, 2, 35128 Padua, Italy.
Alessandra BiasioloDepartment of Medicine, University of Padua, via Giustiniani, 2, 35128 Padua, Italy.
Monica ChinellatoDepartment of Medicine, University of Padua, via Giustiniani, 2, 35128 Padua, Italy.
Cristian TuratoDepartment of Molecular Medicine, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.
Maristella MaggiDepartment of Molecular Medicine, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.
Laura CendronDepartment of Biology, University of Padua, via Bassi 58/B, 35121 Padua, Italy.
Sara N RichterDepartment of Molecular Medicine, University of Padua, via Gabelli 63, 35128 Padua, Italy.ORCID 0000-0002-5446-9029
Patrizia PontissoDepartment of Medicine, University of Padua, via Giustiniani, 2, 35128 Padua, Italy.ORCID 0000-0003-2077-9202

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research has proposed several host factors required for SARS-CoV-2 infection and involved in the inflammatory response. Among these, members of the human serpin family and PAR2 have been suggested to play a relevant role. As it has been shown that one of the multiple activities of protease inhibitor SerpinB3 is the activation of PAR2, we have modulated the expression of these two molecules on both human bronchial and hepatic cells and assessed cell surface Spike binding and SARS-CoV-2 infectivity. Our findings indicate that both SerpinB3 and PAR2 play a pivotal role in viral infection and downregulate the expression of interferon-γ, a cytokine with a well-known antiviral effect. These results underscore the potential of the SerpinB3-PAR2 axis as a target for antiviral therapy and provide support for addressing serpins as targets for this purpose.

Indexed as

Antigens, NeoplasmCOVID-19Receptor, PAR-2SARS-CoV-2SerpinsHumansInterferon-gammaSpike Glycoprotein, CoronavirusAntigens, NeoplasmF2RL1 protein, humanInterferon-gammaReceptor, PAR-2SerpinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2squamous cell carcinoma-related antigenCalu-3HepG2 cellsProtease Activated Receptor 2SARS-CoV-2 infectionSerpinB3Spike

Identifiers

PMID40408638
PMCPMC12442068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.