Evidence map›Paper›PMID 40408625›Full record

ArticleNeurology2025

Clinical Reasoning: A 57-Year-Old Man With Chronic Gait Unsteadiness and Diminished Lower Extremity Sensation.

Radhika Rawat, Sarah Marie Brooker, Grace Elizabeth Naylor, Marcello Cherchi, Puneet Opal

Abstract readCase Reports
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Radhika RawatMedical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-6101-2625
Sarah Marie BrookerDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-5674-3124
Grace Elizabeth NaylorDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Marcello CherchiDepartment of Neurology, University of Chicago, IL; and.ORCID 0000-0002-9371-4488
Puneet OpalDenning Ataxia Center, Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 57-year-old man presented with a 5-year history of progressive gait unsteadiness, diminished lower extremity sensation, and a chronic cough. His symptoms began as episodic balance issues and visual disturbances but progressively worsened, leading to frequent tripping. Physical examination revealed sensory deficits in the lower extremities and cerebellar signs, including nystagmus, dysmetria, and a broad-based gait. Readers will walk through a stepwise approach to the case, developing a comprehensive differential diagnosis and questioning likely etiologies to arrive at a final diagnosis. This case illustrates the challenges of diagnosing complex ataxia and highlights the importance of considering multisystem disorders.

Indexed as

Clinical ReasoningGait Disorders, NeurologicLower ExtremitySensation DisordersDiagnosis, DifferentialHumansMaleMiddle Aged

Identifiers

PMID40408625
PMCPMC12101898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.