ArticleJornal brasileiro de nefrologia
KIM-1 as a biomarker of kidney tubular damage in normoalbuminuric patients with type 2 diabetes mellitus and insulin resistance.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Biomarkers in Diabetic Kidney Disease: Early Detection, Prognostic Assessment, and Integration with Multi-Omics Signatures.Life (Basel, Switzerland) · 2026Review
- Joint effect of hepatic steatosis index and triglyceride glucose index on cardio-renal outcomes: a real-world study.Journal of diabetes and metabolic disorders · 2026Article
- Abnormal lipid metabolism in senescent renal tubular cells in diabetic nephropathy.Cellular and molecular life sciences : CMLS · 2026Review
- Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026Review
- Sulfur-Rich Garlic Extract (DNR) as a Promising Natural Therapeutic for Diabetic Nephropathy: Evidence from aInternational journal of molecular sciences · 2025Article
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4 authors.
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Abstract
introductionInsulin resistance (IR) is associated with diabetic kidney disease (DKD), and normoalbuminuric patients may present with renal tubular damage associated with insulin resistance (RTDAIR). In this context, the kidney injury molecule-1 (KIM-1) emerges as a useful biomarker for assessing tubular damage.
objectiveTo investigate the role of KIM-1 in the detection of RTDAIR in normoalbuminuric patients, as well as its relationship with HOMA-IR. METHODOLOGY: This was a cross-sectional study involving 82 normoalbuminuric patients with T2DM, divided into two groups according to HOMA-IR. Laboratory tests were performed, and data were analyzed using Student's t-test. A p-value < 0.05 was considered significant.
resultsPatients with higher IR (HOMA-IR ≥ 2.77) had increased urinary KIM-1 (uKIM-1) concentrations (113.3 ± 65.0 ng/g creatinine), which may indicate incipient DKD.
conclusionIncreased HOMA-IR may be related to elevated uKIM-1 levels, suggesting that IR contributes to the development of RTDAIR. Furthermore, uKIM-1 may serve as a useful biomarker for its detection.
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