Evidence map›Paper›PMID 40408471›Full record

ArticleScience advances2025

A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K

Wei Zhang, Victoria L Palfini, Yu Wu, Xiaoyun Ding, Allison J Melton, Yudong Gao, Yuki Ogawa, Matthew N Rasband

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei ZhangDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1447-6144
Victoria L PalfiniDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2497-0680
Yu WuDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0001-5617-3141
Xiaoyun DingDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9786-6630
Allison J MeltonDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0547-2678
Yudong GaoDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2371-4693
Yuki OgawaDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2126-9087
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8184-2477

Funding

The Molecular Architecture of Axons in Health and DiseaseR35NS122073 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW N RASBAND · 2021 to 2026
$5.6M
Molecular mechanisms of Kv1 channel localization at the axon initial segmentF31NS139435 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Victoria Palfini · 2024 to 2026
$149k
Role of TRIM46 in neuronal polarity in vivoF31NS134125 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI MELTON, ALLISON JACQUELINE · 2023 to 2025
$146k
NINDS NIH HHS F31 NS134125NINDS NIH HHS F31 NS139435NINDS NIH HHS R35 NS122073
6 · The paper itself

Abstract

Action potentials are initiated and modulated at the axon initial segment (AIS) by highly clustered ion channels. Voltage-gated Kv1 potassium channels underlie most outward AIS K

Indexed as

Axon Initial SegmentAxonsPDZ DomainsShaker Superfamily of Potassium ChannelsAnimalsHEK293 CellsHumansKv Channel-Interacting ProteinsMembrane ProteinsProtein BindingRatsKv Channel-Interacting ProteinsMembrane ProteinsShaker Superfamily of Potassium Channels

Identifiers

PMID40408471
PMCPMC12101511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.