ArticlePloS one2025
Neuronal number and somal volume in calbindin-expressing neurons of the marmoset dorsal lateral geniculate nucleus are preserved during aging.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Age-related dopaminergic integrity in the SNpc and VTA: morphometric and volumetric findings in marmoset (Frontiers in neuroanatomy · 2026Article
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10 authors.
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Abstract
Compelling evidence links age-related brain dysfunction and neurodegenerative processes to persistent disruptions in intracellular calcium (Ca2+) signaling, a central hypothesis in the Ca2+ theory of aging. Calbindin (CB), a classical Ca2+ buffer, has been implicated in region-specific susceptibility to aging-related effects. Specifically, CB-immunopositive (CB+) neurons have demonstrated an age-dependent decline in neuronal number across various cortical and subcortical regions. However, it remains unclear whether this decrease occur in the dorsal lateral geniculate nucleus (DLG), a crucial relay and modulatory center for visual processing. Additionally, the potential impact of aging on the cellular volume of CB+ neurons in the DLG has not been fully elucidated, albeit an age-dependent neuronal hypertrophy of this region has been reported. To address these questions, we investigated CB+ neurons in the DLG of six marmosets (Callithrix jacchus), aged between 29-143 months. Using design-based stereological techniques, we estimated the total number and somal volume of CB+ neurons in DLG layers. Our results revealed no signs of CB+ neuronal number loss and somal volumetric changes in aged DLG, particularly within the koniocellular layers, a stratum that primarily expresses CB and play a critical role in blue/yellow color vision. Altogether, our findings suggest a preserved neuronal number and cellular volume of the CB+ population during aging process in the marmoset DLG. Moreover, they provide a valuable basis for future investigations into the neuroprotective role of CB in visual processing during aging and open avenues for strategies designed to preserve vulnerable neuronal populations in age-related neurodegenerative conditions.
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