ArticleRheumatology (Oxford, England)2025
Does body composition matter in patients with systemic sclerosis?
Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Effectiveness and Impact on Quality of Life of a Hand Rehabilitation Program in Longstanding Systemic Sclerosis: A Prospective, Non-Randomized, Controlled Pilot Study.Journal of clinical medicine · 2026Article
- Quantitative computed tomography body composition analysis for risk stratification in bronchiectasis.Respiratory research · 2026Article
- Insulin Resistance in Systemic Sclerosis: Decoding Its Association with Severe Clinical Phenotype.Journal of clinical medicine · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBody composition plays a significant role in various rheumatic and autoinflammatory diseases. The aim of our study was to assess the impact of muscle mass and subcutaneous adipose tissue quality and quantity in patients with SSc.
methodsAdults with SSc referring to our tertiary centre who underwent high-resolution chest CT (HRCT) to assess pulmonary involvement were included. A semi-automatic segmentation of the subcutaneous fat and paravertebral muscle was performed at the level of the 12th dorsal vertebra, and body composition metrics were collected (subcutaneous fat and paravertebral muscle area and density). Stepwise linear regression analysis was applied to evaluate if body composition, demographics and pulmonary function tests acted as predictors of mortality. Considering patients with muscle Hu values <30 as affected by myosteatosis, we used the odds-risk ratio to assess if it is associated with a higher risk of mortality.
resultsEighty-seven SSc patients (77 females, age 60 ± 15 years, 61% affected by limited cutaneous SSc) were included. The linear model demonstrated that lower DLCO (P = 0.047), higher BMI (P = 0.013), higher density of the subcutaneous fat (P = 0.005) and lower skeletal muscle index (P < 0.001) acted as predictors of mortality. Overall, 63 patients (72%) were affected by myosteatosis (i.e. Hu <30 Hu) and patients affected by muscle fat infiltration at CT showed a 3.345 times higher mortality risk (95% CI 0.396-28.295).
conclusionPatients with SSc are affected by myosteatosis and pre-sarcopenia and body composition seems to influence the overall outcome.
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