Evidence map›Paper›PMID 40408128›Full record

ArticleInorganic chemistry2025

Cyclodextrin-Based Metal-Organic Framework as an Application Platform for Bioactive Ruthenium(III) Complexes.

Mahya Asgharian Marzabad, Sára Kollárová, Fangfang Pan, Martin Novák, Jan Kuta, Kari Rissanen, Pavel Babica, Radek Marek, Ondřej Jurček

Abstract read
In one paragraph

Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahya Asgharian MarzabadDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czechia.ORCID 0000-0002-3515-4611
Sára KollárováDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czechia.
Fangfang PanCollege of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China.
Martin NovákDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czechia.
Jan KutaRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czechia.ORCID 0000-0002-5776-9596
Kari RissanenDepartment of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014 Jyväskylä, Finland.ORCID 0000-0002-7282-8419
Pavel BabicaRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czechia.
Radek MarekDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czechia.ORCID 0000-0002-3668-3523
Ondřej JurčekDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium(III) complexes are promising anticancer metallodrugs because of their antimetastatic (migrastatic) potential and significantly lower host toxicity than generally used platinum metallodrugs. On the other hand, the ruthenium(III) complexes generally show low solubility and stability in an aqueous environment but exhibit some toxicity associated with unspecific delivery. For these reasons, numerous ongoing studies deal with their encapsulation into various delivery systems to maximize their therapeutic efficacy. One of these systems can also be crystals of nontoxic metal-organic frameworks (MOFs). In this work, we studied incorporation of a bioactive ruthenium(III) complex (RuC) inside MOFs derived from γ-cyclodextrin (γ-CD) and biocompatible potassium ions, forming CD-MOF-1. Viability studies

Indexed as

Antineoplastic AgentsCoordination ComplexesCyclodextrinsgamma-CyclodextrinsMetal-Organic FrameworksRutheniumCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHep G2 CellsHumansMolecular StructureAntineoplastic AgentsCoordination ComplexesCyclodextrinsgamma-CyclodextrinsMetal-Organic FrameworksRuthenium

Identifiers

PMID40408128
PMCPMC12152939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.