Evidence map›Paper›PMID 40408062›Full record

ArticleJournal of neuro-oncology2025

Reconsideration of the resection strategy of eloquent brain metastasis in the era of postoperative stereotactic radiotherapy: a comparative analysis with non-eloquent metastasis.

Levin Häni, Danial Nasiri, Antonia Gächter, Artem Klimov, Mattia Branca, Nicole Söll, Andreas Raabe, Daniel M Aebersold, Evelyn Herrmann, Ekin Ermiş and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Levin Häni *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland. levin.haeni@insel.ch.
Danial Nasiri *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.
Antonia GächterDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Artem KlimovDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.
Mattia BrancaCTU Bern, University of Bern, Bern, Switzerland.
Nicole SöllDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.
Andreas RaabeDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.
Daniel M AebersoldDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Evelyn HerrmannDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ekin ErmişDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sonja VulcuDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.
Nicolas Bachmann *Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Philippe Schucht *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo decrease the recurrence rate after complete resection of a brain metastasis, removal of a surgical safety margin is advocated. This is not always feasible when resecting a metastasis in an eloquent location. We aimed to assess the recurrence rate after resection of metastases in an eloquent location followed by postoperative stereotactic radiotherapy to the resection cavity.

methodsWe retrospectively included patients with 1-3 brain metastases undergoing gross total resection and postoperative stereotactic radiotherapy between 2010 and 2022. Primary endpoint was local recurrence free survival (LRFS). Secondary endpoints were overall survival and distant brain failure free survival. Patients were grouped according to the location of their metastasis into eloquent and non-eloquent. Eloquent localization was considered a surrogate for resection without a surgical safety margin according to our institutional practice.

resultsWe included 193 patients with 201 resected metastases. Ninety-five metastases (47.3%) were classified as eloquent and 106 (52.7%) as non-eloquent. Kaplan-Meier analysis showed no difference in LRFS between eloquent and non-eloquent metastases (HR 0.821, 95%-CI 0.447-1.507, p = 0.523). Only increased preoperative tumor volume was associated with worse LRFS (HR 1.015, 95% CI 1.001-1.028, p = 0.033). There was no difference concerning secondary endpoints between eloquent and non-eloquent metastases.

conclusionOmission of a surgical safety margin in at least a part of the resection cavity due to eloquence of adjacent tissue had no detrimental effect on local control after resection and postoperative stereotactic radiotherapy of a brain metastasis. This could influence the strategy during resection of an eloquent metastasis.

Indexed as

Brain NeoplasmsNeoplasm Recurrence, LocalNeurosurgical ProceduresRadiosurgeryAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesSurvival RateBrain metastasisEloquenceRadiosurgeryResectionStereotactic radiotherapySurgical margin

Identifiers

PMID40408062
PMCPMC12208965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.