Evidence map›Paper›PMID 40408037›Full record

ArticleEndocrine2025

Human-machine collaborative risk assessment model for thyroid nodules based on local attention and multi-scale feature extraction: a multi-center clinical study.

Shunlan Liu, Yang Yang, Mingli Cai, Zhirong Xu, Shaozheng He, Qichen Su, Peizhong Liu, Guorong Lyu

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Shunlan LiuDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Yang YangCollege of Engineering, Huaqiao University, Quanzhou, China.
Mingli CaiDepartment of Ultrasound Medicine, Jinjiang Municipal City Hospital, Quanzhou, China.
Zhirong XuDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Shaozheng HeDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Qichen SuDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Peizhong LiuCollege of Engineering, Huaqiao University, Quanzhou, China. pzliu@hqu.edu.cn.
Guorong LyuDepartment of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. lgr_feus@sina.com.

Funding

the Fujian Provincial Joint Fund for Scientific and Technological Innovation Projects 2024Y9386the Graduate Education and Teaching Research Project of Fujian Medical University Y24013the Quanzhou High-Level Talent Innovation and Entrepreneurship Program 2024QZC009YRthe Quanzhou Science and Technology Program 2019C076R
6 · The paper itself

Abstract

purposeWe aimed to evaluate a human-machine collaborative risk assessment model for thyroid nodules using local attention mechanisms and multi-scale feature extraction and compare its performance with those of radiologists of varying experience levels.

methodsA multi-center diagnostic study was conducted using ultrasound image datasets from six hospitals in China. The model was trained on 8397 images from 8063 patients (training set) and validated on 253 images from 245 patients across multiple centers. The diagnostic performance of the model was compared with those of radiologists with varying levels of experience. An assistive strategy was developed where radiologists adjusted their diagnoses based on model results.

resultsThe model achieved recognition accuracies of 0.966, 0.809, 0.826, 0.837, and 0.861 for composition, echogenicity, margin, echogenic foci, and orientation, respectively. The area under the receiver operating characteristic curve (AUROC) for the model in diagnosing benign and malignant nodules was 0.882, significantly higher than that of the junior radiologist (0.789; P < 0.0001). The AUROC of the model was between that of the intermediate (0.837) and senior (0.892) radiologists, with no significant difference compared to either group (both P > 0.05). The assistive strategy improved the AUROC for the junior radiologist from 0.789 to 0.859 (P < 0.0001) and increased sensitivity from 66.11% to 80.00% (P < 0.05), with specificity unchanged.

conclusionThe model accurately identified thyroid nodule risk features and enhanced diagnostic performance, particularly for the junior radiologist, improving sensitivity in diagnosing thyroid nodules.

Indexed as

Thyroid NoduleAdultAgedChinaFemaleHumansMaleMiddle AgedRisk AssessmentUltrasonographyComputer-aided systemHuman–machine collaborativeThyroid nodulesUltrasound

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.