ArticleAnnals of surgical oncology2025
Validation of Invasive Area for Predicting Sentinel Node Status and Survival in Primary Cutaneous Melanoma.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo-dimensional histologic features have demonstrated independent prognostic value for survival in primary cutaneous melanoma, but their predictive value for sentinel node (SN) status has yet to be validated. We aimed to demonstrate the predictive value of the previously described calculated tumor area (CTA), and the novel Simplified Breslow Area (SBA), for SN metastasis and survival. MATERIALS AND
methodsA total of 177 primary melanomas were assessed for standard histological characteristics, maximum invasive width (IW) of the primary tumor and CTA. We simplified CTA measurement by transforming IW with Breslow thickness (BT) [ln(IW) + ln (BT)], yielding SBA. Multivariate analysis was undertaken to assess the performance of CTA and SBA, respectively, as independent predictors of both SN status and survival outcomes.
resultsThe SN + rate was 18.1% (32/177). The median CTA for SN-patients was 3.2 mm
conclusionsThe two-dimensional histologic features CTA and SBA are independently prognostic for survival in primary cutaneous melanoma, and SBA may be a better predictor of SN status than BT.
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