Evidence map›Paper›PMID 40408001›Full record

ReviewAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025

Temperature-modulated separation of therapeutic cells, viral vectors, and exosomes using functional polymers.

Kenichi Nagase, Hideko Kanazawa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Temperature-responsive polymers for bioanalytical systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kenichi NagaseGraduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8553, Japan. nagase@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0002-6575-0107
Hideko KanazawaFaculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato, Tokyo, 105-8512, Japan. hkanazawa@keio.jp.

Funding

Japan Society for the Promotion of Science JP21KK0199Japan Society for the Promotion of Science JP22K19899Japan Society for the Promotion of Science JP24K01181
6 · The paper itself

Abstract

In recent decades, advanced therapeutic modalities such as therapeutic cells, viral vectors, and extracellular vesicles (exosomes), have emerged as effective therapies for intractable diseases. These therapeutic modalities produced through bioprocesses must be purified from contaminants. Effective separation methods are essential for optimizing therapeutic modalities. This review highlights innovative temperature-modulated separation methods enabled by the thermoresponsive polymer poly(N-isopropylacrylamide) (PNIPAAm). The design of PNIPAAm-modified interfaces plays a pivotal role in ensuring precise and efficient separation. We summarize the recent advancements in the application of temperature-modulated separation methods for cells, viral vectors, and exosomes, with a focus on the design of PNIPAAm interfaces.

Indexed as

Acrylic ResinsExosomesGenetic VectorsPolymersTemperatureVirusesAnimalsHumansAcrylic ResinsPolymerspoly-N-isopropylacrylamideBiomaterialsPolymer brushRegenerative medicineTemperature-responsive chromatographyThermoresponsive interfaceThermoresponsive polymer

Identifiers

PMID40408001
PMCPMC12307572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.