Evidence map›Paper›PMID 40407992›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Rapidly progressive dementia in tacrolimus neurotoxicity: rare but reversible.

Siddharth Chand, Riya Sharma, Alaipreet Kaur, Saurabh Mishra, Victo Varghese, Manoj Kumar, Raza A Mahdi, Manoj K Goyal, Ritu Shree

Abstract readCase Reports
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siddharth ChandDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Riya SharmaDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Alaipreet KaurDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
Saurabh MishraDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Victo VargheseDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Manoj KumarDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Raza A MahdiDepartment of Nuclear Medicine, PGIMER, Chandigarh, India.
Manoj K GoyalDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India.
Ritu ShreeDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh (PGIMER), Chandigarh, India. ritushree18@gmail.com.ORCID http://orcid.org/0000-0002-2437-5507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTacrolimus is an immunosuppressant agent widely used in organ transplantation. Neurotoxicity due to tacrolimus is frequently reported in the literature with varied presentations from tremors to leukoencephalopathy. Drugs used to prevent graft rejection can cause significant morbidity. CASE PRESENTATION: A 65-year-old male developed rapidly progressive dementia shortly after liver transplantation. Imaging revealed abnormal signal intensities, symmetrically involving bilateral caudate head and putamen with diffusion restriction mimicking CJD. Blood levels of tacrolimus were repeatedly normal. He improved completely over 4-6 weeks after stopping tacrolimus. DISCUSSION: Tacrolimus is used on a daily basis in most post-transplantation patients. Neurotoxicity related to the medications must be kept in the differential list while investigating rapidly progressing dementia. This case highlights the importance of suspecting tacrolimus toxicity even with therapeutic drug levels.

Indexed as

DementiaImmunosuppressive AgentsNeurotoxicity SyndromesTacrolimusAgedDisease ProgressionHumansLiver TransplantationMagnetic Resonance ImagingMaleImmunosuppressive AgentsTacrolimusCognitive impairmentDementiaTacrolimus neurotoxicity

Identifiers

PMID40407992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.