Evidence map›Paper›PMID 40407973›Full record

ReviewMolecular and cellular biochemistry2025

Human TLS DNA polymerase: saviors or threats under replication stress?

Yogendra Singh Rajpurohit, Mitu Lal, Dhirendra Kumar Sharma, Ishu Soni

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The function of Mgs1/WRNIP1 in genome maintenance.Frontiers in molecular biosciences · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yogendra Singh RajpurohitMolecular Biology Division, Bhabha Atomic Research Centre, 2-46-S, Modular Lab, A-Block, Mumbai, 400085, India. ysraj@barc.gov.in.
Mitu LalMolecular Biology Division, Bhabha Atomic Research Centre, 2-46-S, Modular Lab, A-Block, Mumbai, 400085, India.
Dhirendra Kumar SharmaMolecular Biology Division, Bhabha Atomic Research Centre, 2-46-S, Modular Lab, A-Block, Mumbai, 400085, India.
Ishu SoniMolecular Biology Division, Bhabha Atomic Research Centre, 2-46-S, Modular Lab, A-Block, Mumbai, 400085, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The maintenance of genomic stability is crucial for life, threatened by DNA damage from both endogenous and exogenous sources. Cells employ DNA damage response through various repair mechanisms and DNA damage tolerance via translesion synthesis (TLS), to bypass DNA lesions and prevent replication fork collapse. This review explores the roles of human TLS polymerases in navigating replication stress, a critical process that can lead to genomic instability and cancer. It discusses TLS polymerase's dual role in genome preservation under certain physiological conditions while may also contribute to adaptive mutagenesis, highlighting their significance in DNA damage tolerance, somatic hypermutations, and cancer therapeutics. Understanding these mechanisms offers insights for developing targeted cancer therapies.

Indexed as

DNA DamageDNA-Directed DNA PolymeraseDNA RepairDNA ReplicationGenomic InstabilityNeoplasmsHumansDNA-Directed DNA PolymeraseCancerDNA damage tolerance (DDT)Genome stabilityHuman Y-family polymerasesPCNA monoubiquitylationProliferating cell nuclear antigen (PCNA)Translesion synthesis (TLS)

Identifiers

PMID40407973
PMCPMC12476452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.