Evidence map›Paper›PMID 40407941›Full record

ArticleOral and maxillofacial surgery2025

Blood pressure and microvascular free flap perfusion in head and neck reconstruction- a retrospective analysis.

Mark Ooms, Philipp Winnand, Marius Heitzer, Nils Vohl, Marie Sophie Katz, Johannes Bickenbach, Frank Hölzle, Ali Modabber

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PubMed Full text at PMC Publisher
In one paragraph

Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark OomsDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. mooms@ukaachen.de.ORCID http://orcid.org/0000-0002-9785-9502
Philipp WinnandDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0001-8315-7684
Marius HeitzerDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0002-9205-6065
Nils VohlDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Marie Sophie KatzDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0001-6625-7712
Johannes BickenbachDepartment of Intensive Care Medicine, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0002-0039-8448
Frank HölzleDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Ali ModabberDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0003-2160-4527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe influence of blood pressure on microvascular free flap perfusion is not fully understood and remains an ongoing topic of debate, as flap perfusion is both a prerequisite for flap viability and a parameter frequently used for postoperative flap monitoring. The aim of this study was to investigate the influence of blood pressure on microvascular free flap perfusion.

methodsPerfusion measurement data obtained with the Oxygen-2-see (O2C) analysis system intraoperatively and postoperatively in 244 patients who underwent microvascular reconstruction of the head and neck region with a fasciocutaneous free flap (FFF) or perforator free flap (PFF) between 2011 and 2020 were analyzed retrospectively. Blood pressure values (i.e., systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MBP)) and perfusion parameters (i.e., flap blood flow, hemoglobin concentration, and hemoglobin oxygen saturation) were evaluated to reveal potential associations.

resultsPostoperative flap blood flow was associated with SBP, DBP, and MBP in PFFs (r = 0.245, p = 0.006; r = 0.239, p = 0.008; r = 0.295, p < 0.001, respectively). These associations also persisted in multivariable analysis (p = 0.036; p = 0.024; p = 0.004, respectively). Postoperative hemoglobin oxygen saturation was associated with SBP and MBP in PFFs (r = 0.253, p = 0.005; r = 0.189, p = 0.036, respectively). The association with SBP also persisted in multivariable analysis (p = 0.005).

conclusionMicrovascular free flap perfusion in PFFs, specifically postoperative flap blood flow and hemoglobin oxygen saturation, is influenced by blood pressure. This suggests that blood pressure might be an adjustable variable for the control of flap perfusion and should be considered as a confounding variable for flap monitoring based on flap perfusion in PFFs.

Indexed as

Blood PressureFree Tissue FlapsHead and Neck NeoplasmsPerforator FlapPlastic Surgery ProceduresAdultAgedFemaleHumansMaleMiddle AgedOxygen SaturationRegional Blood FlowRetrospective StudiesBlood flowBlood pressureFree flapHemoglobin concentrationHemoglobin oxygen saturationMicrovascular head and neck reconstruction

Identifiers

PMID40407941
PMCPMC12102101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.