ArticleLasers in medical science2025
Water-soluble porphyrin-mediated enhanced photodynamic and chemotherapy employing doxorubicin for breast cancer.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Mechanically Triggered DNA Nanovehicles for Targeted Dual-Drug Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Standardized Workflows for Time-Resolved Singlet Oxygen Quantification in Aqueous Systems.JACS Au · 2026Article
- Folic acid-functionalized mesoporous silica nanoparticles integrating fluorouracil-derived carbon dots and porphyrin for targeted breast cancer chemo-photodynamic therapy.RSC advances · 2026Article
- Beyond traditional therapies: a narrative overview of antimicrobial photodynamic therapy in combating bacterial and viral infections.Archives of microbiology · 2025Review
- The Current State of Research in the Field of Photosensitizers and Photoactivators for Photodynamic/Photothermal Cancer Therapy: A Review.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the second most common cancer globally and the leading cause of cancer-related deaths in women. Current treatments, such as chemotherapy and surgery, often have side effects and can lead to drug resistance. Developing new treatments that specifically target cancer cells while minimizing side effects is essential. Combining traditional cancer treatments with photodynamic therapy (PDT) is a promising approach. This study evaluated the effectiveness of femtosecond laser-driven PDT using Doxorubicin (DOX) and tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP), both individually and in combination, on MDA-MB-231 and T47D breast cancer cells. TMPyP-PDT and DOX monotherapy both exhibited dose-dependent cytotoxicity. However, combination therapy was more effective at lower DOX concentrations, potentially reducing side effects. This combination also increased reactive oxygen species (ROS) levels, inhibited angiogenesis by reducing TGF-β and VEGFA expression, and induced apoptosis by decreasing BCL-2 and increasing BAX levels compared to individual treatments. These findings suggest that combining TMPyP-mediated PDT with Doxorubicin could effectively inhibit breast cancer cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.