Evidence map›Paper›PMID 40407928›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2025

Effectiveness of pre-operative chemical component separation with computed tomography-guided intramuscular injection of OnabotulinumtoxinA in outcomes of large complex incisional ventral abdominal hernia repair: a propensity score-weighted comparative analysis.

Younes Jahangiri, Dylan Goldsmith, Amy Banks-Venegoni, Gregory Fritz, Giuseppe Zambito, Albert Jiao, Lane King, Jordan Castle, Khaleel Quasem, James Morrison

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Younes JahangiriDivision of Interventional Radiology, Corewell Health West Michigan, 100 Michigan St. NE, Grand Rapids, MI, 49503, USA. y.jahangiri@gmail.com.ORCID 0000-0002-3328-2919
Dylan GoldsmithDivision of Interventional Radiology, Corewell Health West Michigan, 100 Michigan St. NE, Grand Rapids, MI, 49503, USA.
Amy Banks-VenegoniDepartment of Surgery, Corewell Health West Michigan, Grand Rapids, MI, USA.
Gregory FritzDepartment of Surgery, Corewell Health West Michigan, Grand Rapids, MI, USA.
Giuseppe ZambitoDepartment of Surgery, Corewell Health West Michigan, Grand Rapids, MI, USA.
Albert JiaoDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lane KingDepartment of Anesthesia & Critical Care, The University of Chicago, Chicago, IL, USA.
Jordan CastleDivision of Interventional Radiology, Inland Imaging, Spokane, WA, USA.
Khaleel QuasemCollege of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
James MorrisonDivision of Interventional Radiology, Corewell Health West Michigan, 100 Michigan St. NE, Grand Rapids, MI, 49503, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effectiveness of chemical component separation (CCS) via computed tomography (CT)-guided intramuscular injection of OnabotulinumtoxinA (Botox) in postoperative recurrence of large complex incisional ventral abdominal hernias. MATERIALS AND

methodsA total of 97 patients with large ventral abdominal hernias who underwent complex hernia repair between November 2017 and October 2021 after (n = 37) (Botox) or without (n = 60) Botox injection (no-Botox) were included in the study. Data were summarized as median [min-max] or frequency (%) and analyzed using the Fisher's exact test, Mann-Whitney U test, multivariate logistic regression with backward stepwise selection of covariates and augmented inverse probability-weighted analysis with Stata BE 18.0 at a significance level set at 0.10.

resultsThere was no statistically significant difference between Botox and no-Botox groups in patients' age (64[34-78] vs. 62[24-94], p = 0.885), sex (females: 46% vs. 55%, p = 0.410), body mass index (BMI) (32[19-53] vs. 31[18-50], p = 0.431) and hernia volume (3197[226-24232] vs. 2366[140-24314], p = 0.458). Median follow-up duration was 38[2-72] months in Botox and 48[6-81] months in no-Botox groups (p = 0.010), and all-time hernia recurrence was 8% in Botox and 22% in no-Botox groups, respectively (p = 0.097). In multivariate regression analysis, CCS, hernia volume, implanted mesh type and overall postoperative complications were associated with hernia recurrence. After propensity score weighting for follow-up duration, surgical component separation and postoperative discharge destination, CCS was associated with 71% reduced risk of hernia recurrence (p = 0.045).

conclusionThe results of this study suggests that CT-guided chemical component separation with intramuscular injection of OnabotulinumtoxinA may be effective in reducing the risk of post-surgical recurrence of large complex incisional ventral abdominal hernias.

Indexed as

Botulinum Toxins, Type AHernia, VentralHerniorrhaphyIncisional HerniaPreoperative CareAdultAgedAged, 80 and overFemaleHumansInjections, IntramuscularMaleMiddle AgedPropensity ScoreRecurrenceRetrospective StudiesBotulinum Toxins, Type Aonabotulinum toxin ABotoxComplex herniaComponent separationOnabotulinumtoxinAVentral hernia

Identifiers

PMID40407928
PMCPMC12102115

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