Evidence map›Paper›PMID 40407890›Full record

ArticleEuropean child & adolescent psychiatry2025

Age-related differences in psychopathology within sex chromosome trisomies.

Melissa R Roybal, Siyuan Liu, Isabella G Larsen, Anastasia Wass, Lukas Schaffer, Tiffany Ajumobi, Ethan T Whitman, Allysa Warling, Liv Clasen, Jonathan Blumenthal and 2 more

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In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Melissa R RoybalSection on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Siyuan LiuSection on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Isabella G LarsenSection on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8520-5539
Anastasia WassGeorgetown University School of Medicine, Washington, DC, USA.
Lukas SchafferInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Tiffany AjumobiSchool of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Ethan T WhitmanDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Allysa WarlingHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9412-6357
Liv ClasenSection on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Jonathan BlumenthalSection on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Srishti Rau *Children's National Health System, Center for Autism Spectrum Disorders and Division of Neuropsychology, Washington, DC, USA.
Armin Raznahan *Section on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. raznahana@mail.nih.gov.

Funding

Pediatric Brain ImagingZIAMH002794 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2015
$15.3M
Intramural NIH HHS ZIA MH002794Intramural Research Program ZIAMH002794
6 · The paper itself

Abstract

Sex chromosome trisomies (SCTs) are a group of genetic disorders characterized by presence of a supernumerary sex chromosome, resulting in karyotypes other than XX or XY. These include XXX (Trisomy X), XXY (Klinefelter syndrome), and XYY (Jacobs syndrome). SCTs have been linked to increased risk for psychopathology; however, this relationship warrants additional research. Specifically, little is known regarding potential age-related variation in risk for psychopathology and how this may differ across karyotypes and subdomains of psychopathology. This has important implications for psychoeducation (e.g., informing carriers of the likelihood for varying manifestations with age), personalized care, and research into the mechanisms of pathophysiology. Thus, we used the Child Behavior Checklist (CBCL) to estimate age-related variation in psychopathology in a large cross-sectional sample of SCT carriers (n = 201) and euploidic controls (n = 304) spanning the age range of 5-18 years. We found that elevations of psychopathology in carriers were significantly associated with age in a manner that varied as a combined function of the karyotype and CBCL scale being considered. Post hoc tests revealed there is a uniquely pronounced age-associated increase in severity of social problems in the XYY karyotype, alongside a lack of statistical evidence for age-related variation in the severity of psychopathology for other CBCL domains and SCT karyotypes. Our findings are relevant for advancing the personalization of clinical assessment and monitoring in SCT carriers. They also highlight potential windows of dynamic risk emergence for closer clinical and biological study, as well as opportunities to provide intervention to mitigate future risk.

Indexed as

Mental DisordersSex Chromosome DisordersTrisomyAdolescentAge FactorsChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleSex Chromosome AberrationsXYY KaryotypeDevelopmental psychopathologyNeurogenetic conditionsPsychopathologySex chromosomesSex chromosome trisomy

Identifiers

PMID40407890
PMCPMC12592274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.