Evidence map›Paper›PMID 40407880›Full record

ArticleArchives of gynecology and obstetrics2025

Identification of bilateral fornix and hippocampus in fetuses between 18-36 gestational weeks and establishment of nomograms using ultrasonography.

Nazli Ece Sahin, Ebru Alici Davutoglu, Gorkem Arica, Riza Madazli

Registry-linked trialAbstract read
In one paragraph

Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245056 (Evaluation of the Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07245056 narecruitingnot on this map

Evaluation of the Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia

TypeinterventionalSponsorAnkara Etlik City HospitalRan2025 to 2026Enrolled84ConditionsPre-Eclampsia, HippocampusArmsFHC dimensions in EOPE and control groups
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nazli Ece SahinCerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Istanbul University-Cerrahpasa, Kocamustafapasa, Istanbul, Turkey.ORCID 0000-0003-1634-0117
Ebru Alici DavutogluCerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Istanbul, Turkey. ebru.alicidavutoglu@iuc.edu.tr.
Gorkem AricaCerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Riza MadazliCerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo establish nomograms for the bilateral fornix-hippocampus complex (FHC) length and hippocampus height (HH) in fetuses between 18 + 0 and 36 + 0 weeks of gestation using two-dimensional (2D) sonography and assess potential laterality differences.

methodsA prospective study was conducted on 725 singleton pregnancies at the Maternal-Fetal Medicine Department from January to December 2024. Gestational age was confirmed via first-trimester crown-rump length measurements. Exclusion criteria included maternal chronic diseases, multiple pregnancies, fetal anomalies, and growth restriction. Transabdominal 2D sonography captured FHC and HH measurements in the parasagittal plane. Laterality was determined before imaging, and each measurement was repeated twice for reliability. Percentiles (5th, 50th, and 95th) were calculated, and Pearson correlation coefficients assessed relationships with gestational age. The independent samples t-test compared left and right measurements, and intraobserver reliability was evaluated with the intraclass correlation coefficient (ICC).

resultsNomograms with 5th, 50th, and 95th percentiles were established for both sides. The Pearson correlation coefficients for the left and right sides of the FHC length and HH with advancing gestational age were 0.808, 0.808, 0.725, and 0.734, respectively. The correlation coefficients between FHC length and HH for the left and right sides were 0.814 and 0.818, respectively. No significant laterality differences were found (p > 0.05). DISCUSSION: These nomograms provide reference data for assessing fetal neurodevelopment. They may aid in detecting abnormalities, particularly in corpus callosum agenesis and ventriculomegaly.

Indexed as

Fornix, BrainHippocampusNomogramsUltrasonography, PrenatalAdultFemaleGestational AgeHumansPregnancyPregnancy Trimester, ThirdProspective StudiesReproducibility of ResultsFetal brainFornixHippocampusNeurosonographyNomograms

Identifiers

PMID40407880
PMCPMC12334476

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.