Evidence map›Paper›PMID 40407865›Full record

Trial reportNaunyn-Schmiedeberg's archives of pharmacology2025

Pharmacokinetics, bioequivalence, and food effect assessment of enteric-coated aspirin tablets: a randomized, single-dose, four-period crossover study in Chinese healthy subjects.

Minwan Hu, Shuyu Zhang, Peng Xu, Jiangfan Li, Hongxian Pang, Man Yang, Fangyu Chen, Baoqing Gao, Xuhong Wang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minwan Hu *Department of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, 101149, P.R, China.
Shuyu Zhang *Anesthesiology Class 211, First Clinical Medical College of Nanchang University, Nanchang, 330008, P.R, China.
Peng XuNanjing Daoqun Pharmaceutical R & D Co., Ltd, Nanjing, 310024, P.R, China.
Jiangfan LiDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, 101149, P.R, China.
Hongxian PangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, 101149, P.R, China.
Man YangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, 101149, P.R, China.
Fangyu ChenBeijing Nuokangda Pharma Co., Ltd, Beijing, 100176, P.R, China.
Baoqing GaoBeijing Nuokangda Pharma Co., Ltd, Beijing, 100176, P.R, China.
Xuhong WangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, 101149, P.R, China. medicalwangxh@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the pharmacokinetics, bioequivalence, and food effect of two enteric-coated aspirin tablets (100 mg) in healthy Chinese subjects. Ninety subjects were enrolled and divided into fasted (n = 42) and fed cohorts (n = 48) in a single-center, randomized, open-label, single-dose, four-period, two-sequence and crossover study. The pharmacokinetic characteristics of acetylsalicylic acid (aspirin) and its metabolite salicylic acid, including C

Indexed as

AspirinFood-Drug InteractionsPlatelet Aggregation InhibitorsAdministration, OralAdultArea Under CurveAsian PeopleCross-Over StudiesFemaleHealthy VolunteersHumansMaleTablets, Enteric-CoatedTherapeutic EquivalencyYoung AdultAspirinPlatelet Aggregation InhibitorsTablets, Enteric-CoatedAcetylsalicylic acidBioequivalenceEnteric-coated aspirin tabletsPharmacokineticsSalicylic acid

Identifiers

PMID40407865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.